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Substance Name: Colchicine, 17,17,17-trifluoro-
RN: 26195-65-3
InChIKey: MCHADYPYCJQLMV-AWEZNQCLSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H22-F3-N-O6

Molecular Weight

  • 453.4108
 
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Names and Synonyms

Synonyms

  • 17,17,17-Trifluorocolchicine
  • BRN 3021687
  • N-Deacetyl-N-(trifluoroacetyl)colchicine
  • NSC 305987

Systematic Name

  • Colchicine, 17,17,17-trifluoro-

Registry Numbers

CAS Registry Number

  • 26195-65-3

System Generated Number

  • 0026195653

Structure Descriptors

InChI

1S/C22H22F3NO6/c1-29-16-8-6-12-13(10-15(16)27)14(26-21(28)22(23,24)25)7-5-11-9-17(30-2)19(31-3)20(32-4)18(11)12/h6,8-10,14H,5,7H2,1-4H3,(H,26,28)/t14-/m0/s1

InChIKey

MCHADYPYCJQLMV-AWEZNQCLSA-N

Smiles

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 456ug/kg (0.456mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981.
mouse LD50 intraperitoneal 844mg/kg (844mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 636, 1981.