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Substance Name: Periciazine [INN]
RN: 2622-26-6
UNII: 3405M6FD73
InChIKey: LUALIOATIOESLM-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-N3-O-S

Molecular Weight

  • 365.4987
 
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Names and Synonyms

Name of Substance

  • Periciazine
  • Periciazine [INN]
  • Pericyazine

Synonyms

  • 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
  • 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
  • 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
  • 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-
  • 6909 RP
  • Aolept
  • Bayer 1409
  • BRN 0576739
  • Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine
  • Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French]
  • EINECS 220-071-3
  • F.I. 6145
  • IC 6002
  • Nemactil
  • Neulactil
  • Neuleptil
  • Periciazina
  • Periciazina [INN-Spanish]
  • Periciazine
  • Periciazinum
  • Periciazinum [INN-Latin]
  • Pericyazine
  • Piperocyanomazine
  • Propericiazine
  • RP 8908
  • RP 8909
  • SKF 20,716
  • SKF 20716
  • UNII-3405M6FD73
  • WH 7508

Systematic Names

  • 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
  • Periciazine
  • Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)-

Registry Numbers

CAS Registry Number

  • 2622-26-6

FDA UNII

  • 3405M6FD73

System Generated Number

  • 0002622266

Structure Descriptors

InChI

1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2

InChIKey

LUALIOATIOESLM-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)N(c3cc(ccc3S2)C#N)CCCN4CCC(CC4)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
mouse LD50 intraperitoneal 115mg/kg (115mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse LD50 intravenous 27700ug/kg (27.7mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
mouse LD50 oral 530mg/kg (530mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse LD50 subcutaneous 375mg/kg (375mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
rat LD50 intraperitoneal 85mg/kg (85mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat LD50 intravenous 35mg/kg (35mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat LD50 oral 395mg/kg (395mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat LD50 subcutaneous 1200mg/kg (1200mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 116-117 deg C   EXP
log P (octanol-water) 3.52 (none)   EXP
Water Solubility 38 mg/L 37 EXP
Vapor Pressure 4.03E-13 mm Hg 25 EST
Henry's Law Constant 1.81E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.25E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.