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Substance Name: Mecinarone [INN]
RN: 26225-59-2
UNII: 7B1550J80K
InChIKey: WKEFCGWXBSXUOD-DHZHZOJOSA-N

Note

  • Benzofuran chalcone.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H27-N-O6

Molecular Weight

  • 425.478
 
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Names and Synonyms

Name of Substance

  • Mecinarone
  • Mecinarone [INN]

Synonyms

  • 1-(6-(2-(Dimethylamino)ethoxy)-4,7-dimethoxy-5-benzofuranyl)-3-(4-methoxyphenyl)-2-propen-1-one
  • 1-(6-(2-(Dimethylamino)ethoxy)-4,7-dimethoxy-5-benzofuranyl)-3-(p-methoxyphenyl)-2-propen-1-one
  • 5-(p-Methoxy-cinnamoyl)-4,7-dimethoxy-6-dimethylaminoethoxybenzofuran
  • 5-18-05-00368 (Beilstein Handbook Reference)
  • BRN 1670082
  • EINECS 247-524-8
  • Mecinarona
  • Mecinarona [INN-Spanish]
  • Mecinarone
  • Mecinaronum
  • Mecinaronum [INN-Latin]
  • UNII-7B1550J80K

Systematic Names

  • 1-(6-(2-(Dimethylamino)ethoxy)-4,7-dimethoxy-5-benzofuranyl)-3-(p-methoxyphenyl)-2-propen-1-one
  • 2-Propen-1-one, 1-(6-(2-(dimethylamino)ethoxy)-4,7-dimethoxy-5-benzofuranyl)-3-(p-methoxyphenyl)-
  • Mecinarone

Registry Numbers

CAS Registry Number

  • 26225-59-2

FDA UNII

  • 7B1550J80K

Related Registry Numbers

  • 26270-59-7 (maleate[1:1])
  • 52171-36-5 (oxalate[1:1])

System Generated Number

  • 0026225592

Structure Descriptors

InChI

1S/C24H27NO6/c1-25(2)13-15-31-23-20(19(26)11-8-16-6-9-17(27-3)10-7-16)21(28-4)18-12-14-30-22(18)24(23)29-5/h6-12,14H,13,15H2,1-5H3/b11-8+

InChIKey

WKEFCGWXBSXUOD-DHZHZOJOSA-N

Smiles

COc1ccc(\C=C\C(c2c(OC)c3c(c(OC)c2OCCN(C)C)occ3)=O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 63mg/kg (63mg/kg)   Drugs of the Future. Vol. 1, Pg. 133, 1976.
mouse LD50 intravenous 25mg/kg (25mg/kg)   Drugs of the Future. Vol. 1, Pg. 133, 1976.
mouse LD50 oral 244mg/kg (244mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 782, 1975.