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Substance Name: Cyclofenil [INN:BAN:DCF:JAN]
RN: 2624-43-3
UNII: J468V64WZ1
InChIKey: GVOUFPWUYJWQSK-UHFFFAOYSA-N

Note

  • A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.

Molecular Formula

  • C23-H24-O4

Molecular Weight

  • 364.4386
 

Classification Codes

  • Drug / Therapeutic Agent
  • Fertility Agents
  • Fertility Agents, Female
  • Human Data
  • Reproductive Control Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Cyclofenil
  • Cyclofenil [INN:BAN:DCF:JAN]

MeSH Heading

  • Cyclofenil

Synonyms

  • 4,4'-(Cyclohexylidenemethylene)diphenol diacetate ester
  • 4,4'-(Cyclohexylidenmethylen)diphenyl diacetat
  • AI3-52271
  • Bis(p-hydroxyphenyl)cyclohexyldienemethane diacetate
  • Bis-(p-hydroxyphenyl)-cyclohexylidenemethane diacetate
  • BRN 2014687
  • CFN
  • Ciclofenilo
  • Ciclofenilo [INN-Spanish]
  • Cyclofenil
  • Cyclofenilum
  • Cyclofenilum [INN-Latin]
  • Cyclofenyl
  • Cyclopenil
  • Cyclophenil
  • Cyclophenyl
  • EINECS 220-089-1
  • F 6066
  • Fertodur
  • H 3452
  • ICI 48213
  • Neoclym
  • NSC 86464
  • Oginex
  • Ondogyne
  • Ondonid
  • Rehibin
  • Sanocrisin
  • Sexadieno
  • Sexovar
  • Sexovid
  • UNII-J468V64WZ1

Systematic Names

  • 4,4'-(Cyclohexylidenemethylene)diphenol diacetate ester
  • Cyclofenil
  • p-Cresol, alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-, diacetate
  • Phenol, 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-, acetate (9CI)

Registry Numbers

CAS Registry Number

  • 2624-43-3

FDA UNII

  • J468V64WZ1

System Generated Number

  • 0002624433

Structure Descriptors

InChI

1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3

InChIKey

GVOUFPWUYJWQSK-UHFFFAOYSA-N

Smiles

C(\c1ccc(OC(C)=O)cc1)(c1ccc(OC(C)=O)cc1)=C1\CCCCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1080mg/kg (1080mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 821, 1970.
mouse LD50 oral > 12500mg/kg (12500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANOREXIA (HUMAN
Acta Pharmacologica et Toxicologica. Vol. 23, Pg. 365, 1966.
mouse LD50 subcutaneous > 12gm/kg (12000mg/kg)   Drugs in Japan Vol. 6, Pg. 313, 1982.
rat LD50 intraperitoneal 1700mg/kg (1700mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 821, 1970.
rat LD50 oral > 12gm/kg (12000mg/kg)   Drugs in Japan Vol. 6, Pg. 313, 1982.
rat LD50 subcutaneous > 12gm/kg (12000mg/kg)   Drugs in Japan Vol. 6, Pg. 313, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 135.5 deg C   EXP
log P (octanol-water) 5.370 (none)   EST
Atmospheric OH Rate Constant 1.20E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.