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Substance Name: Ethamsylate [USAN]
RN: 2624-44-4
UNII: 24YL531VOH
InChIKey: HBGOLJKPSFNJSD-UHFFFAOYSA-N

Note

  • Benzenesulfonate derivative used as a systemic hemostatic.

Molecular Formula

  • C6-H6-O5-S.C4-H11-N

Molecular Weight

  • 263.3123
 

Classification Codes

  • Coagulants
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Hemostatic
  • Hemostatics
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Etamsylate [INN]
  • Ethamsylate
  • Ethamsylate [USAN]

MeSH Heading

  • Ethamsylate

Synonyms

  • 1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic acid compd. with diethylamine
  • 2,5-Dihydroxybenzenesulfonic acid compd. with N-ethylethanamine
  • 2,5-Dihydroxybenzenesulfonic acid compound with diethylamine (1:1)
  • Aglumin
  • Altodor
  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)
  • Ciclonamina
  • Ciclonamina [Italian]
  • Cyclonamine
  • Dicynene
  • Dicynone
  • Diethylammonium 2,5-dihydroxybenzenesulfonate
  • Diethylammonium cyclohexadien-4-ol-1-one-4-sulfonate
  • Diidroxi-1,4-benzenesulfonato-3-di-etilammonium
  • Diidroxi-1,4-benzenesulfonato-3-di-etilammonium [Italian]
  • E 141
  • EINECS 220-090-7
  • Eselin
  • Etamsilato
  • Etamsilato [INN-Spanish]
  • Etamsylate
  • Etamsylatum
  • Etamsylatum [INN-Latin]
  • Ethamsylate
  • MD 141
  • UNII-24YL531VOH

Systematic Names

  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)
  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine(1:1)
  • Etamsylate

Registry Numbers

CAS Registry Number

  • 2624-44-4

FDA UNII

  • 24YL531VOH

System Generated Number

  • 0002624444

Molecular Formulas

Molecular Formula

  • C6-H6-O5-S.C4-H11-N

Molecular Formula Fragments

  • C4-H11-N
  • C6-H6-O5-S
  • COMPONENT

Structure Descriptors

InChI

1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3

InChIKey

HBGOLJKPSFNJSD-UHFFFAOYSA-N

Smiles

CCNCC.c1cc(c(cc1O)S(=O)(=O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Therapie. Vol. 15, Pg. 110, 1960.
guinea pig LD50 oral 3500mg/kg (3500mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT
Toksikologicheskii Vestnik. Vol. (5), Pg. 40, 1995.
mouse LD50 intramuscular > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
mouse LD50 intraperitoneal 29750mg/kg (29750mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT
Toksikologicheskii Vestnik. Vol. (5), Pg. 40, 1995.
mouse LD50 intravenous 760mg/kg (760mg/kg)   Drugs in Japan Vol. -, Pg. 217, 1995.
mouse LD50 oral 8300mg/kg (8300mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
mouse LD50 subcutaneous 6040mg/kg (6040mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
rat LD50 intramuscular > 4mg/kg (4mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
rat LD50 intravenous 1350mg/kg (1350mg/kg)   Therapie. Vol. 15, Pg. 110, 1960.
rat LD50 oral 7500mg/kg (7500mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
rat LD50 subcutaneous 5250mg/kg (5250mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 125 deg C   EXP
log P (octanol-water) -0.110 (none)   EST
Atmospheric OH Rate Constant 2.29E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.