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Substance Name: Cinepazide maleate [JAN]
RN: 26328-04-1
UNII: Y35B3VA60V
InChIKey: XSTJTOKYCAJVMJ-GVTSEVKNSA-N

Note

  • Systemic, coronary & cerebral vasodilator agent.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C22-H31-N3-O5.C4-H4-O4

Molecular Weight

  • 533.5745
 
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Names and Synonyms

Name of Substance

  • Cinepazide maleate
  • Cinepazide maleate [JAN]

Synonyms

  • 1-((1-Pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine maleate
  • 1-(4-((3',4',5'-Trimethoxycinnamoyl)-1-piperazinyl)acetyl)pyrrolidine maleate
  • 4-(3,4,5-Trimethoxycinnamoyl)-1-(1-pyrrolidinyl)carbonylmethylpiperazine maleate
  • Brendil
  • Cinepazide maleate
  • EINECS 247-613-1
  • Maleate de cinepazide
  • Maleate de cinepazide [French]
  • MD 67350
  • NSC 291562
  • UNII-Y35B3VA60V
  • Vasodistal

Systematic Names

  • 1-(2-Oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)piperazine (Z)-2-butenedioate (1:1)
  • 1-(2-Oxo-2-pyrrolidin-1-ylethyl)-4-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperazine monomaleate
  • Piperazine, 1-((1-pyrrolidinylcarbonyl)methyl)-4-(3',4',5'-trimethoxycinnamoyl)-, maleate
  • Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (Z)-2-butenedioate (1:1) (9CI)

Registry Numbers

CAS Registry Number

  • 26328-04-1

FDA UNII

  • Y35B3VA60V

Other Registry Number

  • 53529-16-1

System Generated Number

  • 0026328041

Molecular Formulas

Molecular Formula

  • C22-H31-N3-O5.C4-H4-O4

Molecular Formula Fragments

  • C22-H31-N3-O5
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

InChIKey

XSTJTOKYCAJVMJ-GVTSEVKNSA-N

Smiles

COc1cc(\C=C\C(=O)N2CCN(CC(=O)N3CCCC3)CC2)cc(OC)c1OC.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 617mg/kg (617mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 29, Pg. 29, 1974.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 29, Pg. 29, 1974.
mouse LD50 subcutaneous 946mg/kg (946mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 407, 1979.
rat LD50 intravenous 414mg/kg (414mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 29, Pg. 29, 1974.
rat LD50 oral 1310mg/kg (1310mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR
Therapie. Vol. 29, Pg. 29, 1974.
rat LD50 subcutaneous 710mg/kg (710mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 407, 1979.