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Substance Name: Zotepine [INN:BAN:JAN]
RN: 26615-21-4
UNII: U29O83JAZW
InChIKey: HDOZVRUNCMBHFH-UHFFFAOYSA-N

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Molecular Formula

  • C18-H18-Cl-N-O-S

Molecular Weight

  • 331.8652
 
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Names and Synonyms

Name of Substance

  • Zotepine
  • Zotepine [INN:BAN:JAN]

Synonyms

  • 2-((8-Chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethanamine
  • 2-((8-Chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine
  • 2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin
  • 2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin [German]
  • 2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
  • 2-Chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine
  • 5-17-04-00588 (Beilstein Handbook Reference)
  • BRN 1435710
  • Compound-4
  • Lodopin
  • Nipolept
  • UNII-U29O83JAZW
  • Zotepina
  • Zotepina [INN-Spanish]
  • Zotepina [Spanish]
  • Zotepine
  • Zotepinum
  • Zotepinum [INN-Latin]

Systematic Names

  • 2-((8-Chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine
  • Dibenzo(b,f)thiepin, 2-chloro-11-(2-(dimethylamino)ethoxy)-
  • Ethanamine, 2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethyl-

Registry Numbers

CAS Registry Number

  • 26615-21-4

FDA UNII

  • U29O83JAZW

System Generated Number

  • 0026615214

Structure Descriptors

InChI

1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

InChIKey

HDOZVRUNCMBHFH-UHFFFAOYSA-N

Smiles

c12c(Sc3ccccc3C=C1OCCN(C)C)ccc(c2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 26600ug/kg (26.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
dog LD50 oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
mouse LD50 intraperitoneal 36200ug/kg (36.2mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
mouse LD50 intravenous 43300ug/kg (43.3mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
mouse LD50 oral 108mg/kg (108mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
mouse LD50 subcutaneous 84900ug/kg (84.9mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rabbit LD50 intravenous 23800ug/kg (23.8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rabbit LD50 oral 250mg/kg (250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rat LD50 intraperitoneal 97mg/kg (97mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rat LD50 intravenous 36800ug/kg (36.8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rat LD50 oral 306mg/kg (306mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.
rat LD50 subcutaneous 1290mg/kg (1290mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1600, 1979.