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Substance Name: Isoflurane [USAN:USP:INN:BAN:JAN]
RN: 26675-46-7
UNII: CYS9AKD70P
InChIKey: PIWKPBJCKXDKJR-UHFFFAOYSA-N

Note

  • A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Molecular Formula

  • C3-H2-Cl-F5-O

Molecular Weight

  • 184.4908
 

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Isoflurane
  • Isoflurane [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Isoflurane

Synonyms

  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
  • AErrane
  • AErrane (Veterinary)
  • BRN 1852087
  • CCRIS 3043
  • Compound 469
  • EINECS 247-897-7
  • Forane
  • Forene
  • HSDB 8057
  • IsoFlo
  • Isoflurane
  • Isoflurano
  • Isoflurano [INN-Spanish]
  • Isofluranum
  • Isofluranum [INN-Latin]
  • R-E 235dal
  • Terrell
  • UNII-CYS9AKD70P

Systematic Names

  • Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
  • Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
  • Isoflurane

Superlist Name

  • Isoflurane [Anaesthetics, volatile]

Registry Numbers

CAS Registry Number

  • 26675-46-7

FDA UNII

  • CYS9AKD70P

System Generated Number

  • 0026675467

Structure Descriptors

InChI

1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H

InChIKey

PIWKPBJCKXDKJR-UHFFFAOYSA-N

Smiles

C(C(F)(F)F)(OC(F)F)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 1071uL/kg (1.071mL/kg)   Journal of Forensic Sciences. Vol. 38, Pg. 968, 1993.
man LDLo oral 1143uL/kg (1.143mL/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Netherlands Journal of Medicine. Vol. 33, Pg. 74, 1988.
mouse LC50 inhalation 16800ppm/3H (16800ppm) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
mouse LD50 intraperitoneal 3030uL/kg (3.03mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
mouse LD50 oral 5080uL/kg (5.08mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
mouse LD50 oral 5080uL/kg (5.08mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
rat LC50 inhalation 15300ppm/3H (15300ppm) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
rat LD50 intraperitoneal 4280uL/kg (4.28mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.
rat LD50 oral 4770uL/kg (4.77mL/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 3031, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 48.5 deg C   EXP
Boiling Point 48.5 deg C   EXP
log P (octanol-water) 2.06 (none)   EXP
Water Solubility 4470 mg/L 37 EXP
Vapor Pressure 591 mm Hg 25 EST
Henry's Law Constant 0.0287 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.51E-14 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.