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Substance Name: Abbott 40174
RN: 26685-57-4
UNII: 5HF6EE0TC4
InChIKey: PNEYWTKVWJBOMD-UHFFFAOYSA-N

Note

  • Tetrahydropyridobenzopyran derived from cannabinoid nucleus.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C26-H37-N-O2

Molecular Weight

  • 395.583
 
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Names and Synonyms

Name of Substance

  • Abbott 40174

Synonyms

  • 8-(1,2-Dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl)-2H-(1)benzopyrano(4,3-c)pyridin-10-ol
  • Abbott 40174
  • NSC 167790
  • SP 1
  • SP 1 (pharmaceutical)
  • SP-1 (VAN)
  • UNII-5HF6EE0TC4

Systematic Names

  • 2H-(1)Benzopyrano(4,3-c)pyridin-10-ol, 8-(1,2-dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl)-
  • 5H-(1)Benzopyrano(4,3-c)pyridine, 1,2,3,4-tetrahydro-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-2-(2-propynyl)-

Registry Numbers

CAS Registry Number

  • 26685-57-4

FDA UNII

  • 5HF6EE0TC4

System Generated Number

  • 0026685574

Structure Descriptors

InChI

1S/C26H37NO2/c1-7-9-10-11-18(3)19(4)20-15-23(28)25-21-17-27(13-8-2)14-12-22(21)26(5,6)29-24(25)16-20/h2,15-16,18-19,28H,7,9-14,17H2,1,3-6H3

InChIKey

PNEYWTKVWJBOMD-UHFFFAOYSA-N

Smiles

C12=C(C(C)(C)Oc3c1c(cc([C@@H]([C@@H](CCCCC)C)C)c3)O)CC[N@@](C2)CC#C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: IRRITABILITY
Journal of Medicinal Chemistry. Vol. 19, Pg. 445, 1976.
mouse LD50 oral 2500mg/kg (2500mg/kg)   Journal of Medicinal Chemistry. Vol. 19, Pg. 454, 1976.
rat LD50 oral 900mg/kg (900mg/kg)   Journal of Medicinal Chemistry. Vol. 19, Pg. 454, 1976.