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Substance Name: Sivifene [USAN:INN]
RN: 2675-35-6
UNII: XAV05295I5
InChIKey: YOQPCWIXYUNEET-UHFFFAOYSA-N

Classification Code

  • Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix and Other Neoplasms

Molecular Formula

  • C19-H14-N4-O6

Molecular Weight

  • 394.3416
 
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Names and Synonyms

Name of Substance

  • Sivifene [USAN:INN]

Synonyms

  • 4,4'-Dihydroxybenzophenone 2,4-dinitrophenylhydrazone
  • 4,4'-Dihydroxybenzophenone-2,4-dinitrophenyl-hydrazone
  • A 007
  • A-007
  • A007
  • Sivifene
  • UNII-XAV05295I5

Systematic Name

  • Methanone, bis(4-hydroxyphenyl)-, (2,4-dinitrophenyl)hydrazone

Registry Numbers

CAS Registry Number

  • 2675-35-6

FDA UNII

  • XAV05295I5

System Generated Number

  • 0002675356

Structure Descriptors

InChI

1S/C19H14N4O6/c24-15-6-1-12(2-7-15)19(13-3-8-16(25)9-4-13)21-20-17-10-5-14(22(26)27)11-18(17)23(28)29/h1-11,20,24-25H

InChIKey

YOQPCWIXYUNEET-UHFFFAOYSA-N

Smiles

[N+](=O)([O-])c1c(ccc([N+](=O)[O-])c1)N/N=C(\c1ccc(cc1)O)c1ccc(cc1)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING In Vivo. Vol. 11, Pg. 29, 1997.
mouse LD50 intraperitoneal 260mg/kg (260mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
In Vivo. Vol. 11, Pg. 29, 1997.
mouse LD50 oral 2690mg/kg (2690mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
In Vivo. Vol. 11, Pg. 29, 1997.
rabbit LD50 ocular > 521nL/kg (521mL/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE In Vivo. Vol. 11, Pg. 29, 1997.
rabbit LD50 skin > 521nL/kg (521mL/kg)   In Vivo. Vol. 11, Pg. 29, 1997.
rat LD50 intraperitoneal 576mg/kg (576mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
In Vivo. Vol. 11, Pg. 29, 1997.
rat LD50 oral 4300mg/kg (4300mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
In Vivo. Vol. 11, Pg. 29, 1997.