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Substance Name: Lofepramine hydrochloride [USAN:JAN]
RN: 26786-32-3
UNII: Z24K96F991
InChIKey: ZWZIQPOLMDPIQM-UHFFFAOYSA-N

Note

  • A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.

Molecular Formula

  • C26-H27-Cl-N2-O.Cl-H

Molecular Weight

  • 455.4262
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Lofepramine hydrochloride
  • Lofepramine hydrochloride [USAN:JAN]

Synonyms

  • 4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenone monohydrochloride
  • 5H-Dibenz(b,f)azepine, 5-(3-((p-chlorobenzoylmethyl)-N-methylamino)propyl)-, hydrochloride
  • Clopepramine hydrochloride
  • DB-2182
  • EINECS 248-002-2
  • Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, monohydrochloride
  • Gamonil
  • Iopramine hydrochloride
  • Leo 640 hydrochloride
  • Lofepramine HCl
  • Lofepramine hydrochloride
  • N-Methyl-N-(4'-chlorophenacyl)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propylamine HCl
  • UNII-Z24K96F991
  • WHR 2908A
  • WHR-2908A

Systematic Names

  • 1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)ethan-1-one monohydrochloride
  • Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, hydrochloride
  • Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 26786-32-3

FDA UNII

  • Z24K96F991

Related Registry Number

  • 23047-25-8 (Parent)

System Generated Number

  • 0026786323

Molecular Formulas

Molecular Formula

  • C26-H27-Cl-N2-O.Cl-H

Molecular Formula Fragments

  • C26-H27-Cl-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C26H27ClN2O.ClH/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29;/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3;1H

InChIKey

ZWZIQPOLMDPIQM-UHFFFAOYSA-N

Smiles

CN(CCCN1c2ccccc2CCc3c1cccc3)CC(=O)c4ccc(cc4)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 920mg/kg (920mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.