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Substance Name: Indapamide [USAN:USP:INN:BAN:JAN]
RN: 26807-65-8
UNII: F089I0511L
InChIKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N
Note
- A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
Molecular Formula
- C16-H16-Cl-N3-O3-S
Molecular Weight
- 365.8394
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretic
- Diuretics
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Natriuretic Agents
- Reproductive Effect
- Sodium Chloride Symporter Inhibitors
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Names and Synonyms
Name of Substance
- Indapamide
- Indapamide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Indapamide
Synonyms
- 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
- 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide
- 5-20-06-00348 (Beilstein Handbook Reference)
- Arifon
- Bajaten
- BRN 1604026
- Cormil
- Damide
- EINECS 248-012-7
- Fludex
- Indaflex
- Indamol
- Indapamida
- Indapamida [INN-Spanish]
- Indapamide
- Indapamidum
- Indapamidum [INN-Latin]
- Ipamix
- Lozol
- Natrilix
- Noranat
- NSC 757075
- Pressurai
- RHC 2555
- SE 1520
- SE-1520
- Tandix
- Tertensif
- UNII-F089I0511L
- USV 2555
- Veroxil
Systematic Names
- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-
- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-l-yl)-
- Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-
- Indapamide
Registry Numbers
CAS Registry Number
- 26807-65-8
FDA UNII
- F089I0511L
Other Registry Number
- 49564-58-1
System Generated Number
- 0026807658
Structure Descriptors
InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)InChIKey
NDDAHWYSQHTHNT-UHFFFAOYSA-NSmiles
CC1Cc2ccccc2N1NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intraperitoneal | 347mg/kg (347mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
guinea pig | LD50 | intravenous | 272mg/kg (272mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
guinea pig | LD50 | oral | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
mouse | LD50 | intraperitoneal | 410mg/kg (410mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
mouse | LD50 | intravenous | 577mg/kg (577mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1110, 1981. | |
rabbit | LD50 | intravenous | 337mg/kg (337mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1110, 1981. |
rat | LD50 | intraperitoneal | 393mg/kg (393mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
rat | LD50 | intravenous | 394mg/kg (394mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1491, 1975. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1110, 1981. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 161 | deg C | EXP | |
log P (octanol-water) | 2.660 | (none) | EST | |
Atmospheric OH Rate Constant | 3.60E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.