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Substance Name: Harringtonine
RN: 26833-85-2
UNII: 088662H40F
InChIKey: HAVJATCHLFRDHY-KSZYUSJVSA-N

Note

  • From Caphalotaxus fortunei.

Molecular Formula

  • C28-H37-N-O9

Molecular Weight

  • 531.5983
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
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Names and Synonyms

Results Name

  • Harringtonine

Name of Substance

  • Harringtonin

Synonyms

  • 2'R-Harringtonine
  • Alkaloid C from cephalotaxus
  • Harringtonin
  • Harringtonine
  • NSC 124147
  • UNII-088662H40F

Systematic Names

  • Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester) (9CI)
  • Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-
  • Cephalotaxine, 4-methyl-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))- (9CI)
  • Harringtonine (8CI)

Registry Numbers

CAS Registry Number

  • 26833-85-2

FDA UNII

  • 088662H40F

Other Registry Numbers

  • 25302-09-4
  • 88455-80-5

System Generated Number

  • 0026833852

Structure Descriptors

InChI

1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1

InChIKey

HAVJATCHLFRDHY-KSZYUSJVSA-N

Smiles

COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4170ug/kg (4.17mg/kg)   Chinese Medical Journal Vol. 92, Pg. 175, 1979.
mouse LD50 intravenous 4500ug/kg (4.5mg/kg)   Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.