Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Isoharringtonine
RN: 26833-86-3
InChIKey: CAOHZEUEVKYHPF-XWHOPEMDSA-N

Note

  • Alkaloid from Cephalotaxus harringtonia.

Molecular Formula

  • C28-H37-N-O9

Molecular Weight

  • 531.598
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Isoharringtonine

Synonyms

  • Cephalotaxine, 4-methyl-2,3-dihydroxy-2-(3-methylbutyl)butanedioate (ester), (3-(2R,3S))-
  • Isoharringtonine
  • NSC 141634

Systematic Names

  • 4-Methylcephalotaxine 2,3-dihydroxy-2-(3-methylbutyl)butanedioate ester
  • Cephalotaxine, 4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate (ester) (9CI)
  • Cephalotaxine, 4-methyl 2,3-dihydroxy-2-(3-methylbutyl)butanedioate (ester), (3(2R,3S))- (9CI)
  • Isoharringtonine

Registry Numbers

CAS Registry Number

  • 26833-86-3

System Generated Number

  • 0026833863

Structure Descriptors

InChI

1S/C28H37NO9/c1-16(2)6-9-28(33,24(30)25(31)35-4)26(32)38-23-21(34-3)14-27-8-5-10-29(27)11-7-17-12-19-20(37-15-36-19)13-18(17)22(23)27/h12-14,16,22-24,30,33H,5-11,15H2,1-4H3/t22-,23-,24-,27+,28-/m1/s1

InChIKey

CAOHZEUEVKYHPF-XWHOPEMDSA-N

Smiles

C=1[C@@]23[C@@H]([C@@H](OC([C@@]([C@@H](C(=O)OC)O)(CCC(C)C)O)=O)C1OC)c1c(cc4c(c1)OCO4)CC[N@@]2CCC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 14600ug/kg (14.6mg/kg)   Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.
mouse LD50 intravenous 13200ug/kg (13.2mg/kg)   Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.
mouse LD50 oral 27950ug/kg (27.95mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 26110ug/kg (26.11mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,