Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Timolol [USAN:INN]
RN: 26839-75-8
UNII: 5JKY92S7BR
InChIKey: BLJRIMJGRPQVNF-JTQLQIEISA-N

Note

  • A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.

Molecular Formula

  • C13-H24-N4-O3-S

Molecular Weight

  • 316.4236
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Neurotransmitter Agents

Names and Synonyms

Results Name

  • Timolol [USAN:INN]

Name of Substance

  • Timolol
  • Timolol [USAN:INN]

MeSH Heading

  • Timolol

Synonyms

  • (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
  • (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
  • Betimol
  • EINECS 248-032-6
  • HSDB 6533
  • Istalol
  • S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
  • Timolol
  • Timolol GFS
  • Timololum
  • Timololum [INN-Latin]
  • Timopic
  • UNII-5JKY92S7BR

Systematic Names

  • (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (2S)-

Mixture Name

  • Azarga

Registry Numbers

CAS Registry Number

  • 26839-75-8

FDA UNII

  • 5JKY92S7BR

Other Registry Numbers

  • 131628-37-0
  • 194288-09-0

Related Registry Number

  • 26921-17-5 (maleate (1:1) salt)

System Generated Number

  • 0026839758

Structure Descriptors

InChI

1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1

InChIKey

BLJRIMJGRPQVNF-JTQLQIEISA-N

Smiles

CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 201.5-203 deg C   EXP
log P (octanol-water) 1.83 (none)   EXP
Water Solubility 2740 mg/L 25 EST
Vapor Pressure 1.08E-09 mm Hg 25 EST
Henry's Law Constant 4.35E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.67E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.