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Substance Name: Indoramin [USAN:INN:BAN]
RN: 26844-12-2
UNII: 0Z802HMY7H
InChIKey: JXZZEXZZKAWDSP-UHFFFAOYSA-N
Note
- An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.
Molecular Formula
- C22-H25-N3-O
Molecular Weight
- 347.4595
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Indoramin
- Indoramin [USAN:INN:BAN]
MeSH Heading
- Indoramin
Synonyms
- 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole
- 5-22-10-00116 (Beilstein Handbook Reference)
- Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-
- BRN 0494035
- EINECS 248-041-5
- Indoramin
- Indoramina
- Indoramina [INN-Spanish]
- Indoramine
- Indoramine [INN-French]
- Indoraminum
- Indoraminum [INN-Latin]
- N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide
- N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide
- UNII-0Z802HMY7H
- WY 21901
Systematic Names
- Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-
- Benzamide, N-(1-(2-indol-3-ylethyl)-4-piperidyl)-
- Indoramin
Registry Numbers
CAS Registry Number
- 26844-12-2
FDA UNII
- 0Z802HMY7H
System Generated Number
- 0026844122
Structure Descriptors
InChI
InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)InChIKey
JXZZEXZZKAWDSP-UHFFFAOYSA-NSmiles
O=C(NC1CCN(CCc2c[nH]c3ccccc23)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 400mg/kg (400mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Medicinal Chemistry. Vol. 14, Pg. 1054, 1971. |
| rat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | Journal of Medicinal Chemistry. Vol. 14, Pg. 1054, 1971. | |
| rat | LD50 | oral | 1800mg/kg (1800mg/kg) | Journal of Medicinal Chemistry. Vol. 14, Pg. 1054, 1971. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 209 | deg C | EXP | |
| log P (octanol-water) | 3.600 | (none) | EST | |
| Atmospheric OH Rate Constant | 3.21E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.