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Substance Name: Penfluridol [USAN:INN:BAN]
RN: 26864-56-2
UNII: 25TLU22Q8H
InChIKey: MDLAAYDRRZXJIF-UHFFFAOYSA-N

Note

  • One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.

Molecular Formula

  • C28-H27-Cl-F5-N-O

Molecular Weight

  • 523.9703
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Penfluridol
  • Penfluridol [USAN:INN:BAN]

MeSH Heading

  • Penfluridol

Synonyms

  • 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol
  • 4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-
  • 5-21-02-00409 (Beilstein Handbook Reference)
  • BRN 1558826
  • EINECS 248-074-5
  • McN-JR-16,341
  • Penfluridol
  • Penfluridolum
  • Penfluridolum [INN-Latin]
  • R 16,341
  • R 16341
  • Semap
  • TLP-607
  • UNII-25TLU22Q8H

Systematic Names

  • 4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-
  • 4-Piperidinol, 1-(4,4-bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-
  • 4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-
  • Penfluridol

Registry Numbers

CAS Registry Number

  • 26864-56-2

FDA UNII

  • 25TLU22Q8H

System Generated Number

  • 0026864562

Structure Descriptors

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChIKey

MDLAAYDRRZXJIF-UHFFFAOYSA-N

Smiles

c1cc(ccc1C(CCCN2CCC(CC2)(c3ccc(c(c3)C(F)(F)F)Cl)O)c4ccc(cc4)F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 90mg/kg (90mg/kg)   European Journal of Pharmacology. Vol. 11, Pg. 139, 1970.
mouse LD50 intraperitoneal 171mg/kg (171mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Drugs under Experimental and Clinical Research. Vol. 4, Pg. 1, 1978.
mouse LD50 oral 87mg/kg (87mg/kg)   European Journal of Pharmacology. Vol. 11, Pg. 139, 1970.
rat LD50 oral 160mg/kg (160mg/kg)   European Journal of Pharmacology. Vol. 11, Pg. 139, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 106 deg C   EXP
log P (octanol-water) 7.840 (none)   EST
Atmospheric OH Rate Constant 5.23E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.