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Substance Name: Etravirine [USAN:INN:BAN:JAN]
RN: 269055-15-4
UNII: 0C50HW4FO1
InChIKey: PYGWGZALEOIKDF-UHFFFAOYSA-N

Note

  • HIV-1 reverse transriptase inhibitor; an anti-HIV agent.

Molecular Formula

  • C20-H15-Br-N6-O

Molecular Weight

  • 435.2835
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • Treatment of HIV Infection

Names and Synonyms

Name of Substance

  • Etravirine
  • Etravirine [USAN:INN:BAN:JAN]

Synonyms

  • 4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile
  • Etravirine
  • ETV
  • Intelence
  • R 165335
  • TMC 125
  • TMC-125
  • TMC125
  • UNII-0C50HW4FO1

Systematic Names

  • 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile
  • Benzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-

Registry Numbers

CAS Registry Number

  • 269055-15-4

FDA UNII

  • 0C50HW4FO1

Other Registry Number

  • 394729-17-0

System Generated Number

  • 0269055154

Structure Descriptors

InChI

InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)

InChIKey

PYGWGZALEOIKDF-UHFFFAOYSA-N

Smiles

Cc1cc(cc(C)c1Oc2nc(Nc3ccc(cc3)C#N)nc(N)c2Br)C#N