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Substance Name: HT-2 Toxin
RN: 26934-87-2
UNII: NC6C26RM46
InChIKey: PNKLMTPXERFKEN-MLXHEQMXSA-N

Classification Codes

  • Natural Product
  • Skin / Eye Irritant

Molecular Formula

  • C22-H32-O8

Molecular Weight

  • 424.4868
 
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Names and Synonyms

Name of Substance

  • HT-2 Toxin

Synonyms

  • 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 15-acetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
  • 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 15-acetate 8-isovalerate
  • HT 2
  • HT 2 Toxin
  • HT-2
  • HT-2 Toxin
  • Mycotoxin HT 2
  • NSC 278571
  • Toxin HT 2
  • UNII-NC6C26RM46

Systematic Names

  • 15-Acetoxy-3,4-dihydroxy-8-(3-methylbutyryloxy)-12,13-epoxy delta9-trichothecene
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15 acetate 8-(3-methylbutanoate), (3alpha,4abeta,8alpha)- (9CI)
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15-acetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)- (9CI)
  • Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 15-acetate, 8-isovalerate
  • Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 15-acetate 8-isovalerate (8CI)

Registry Numbers

CAS Registry Number

  • 26934-87-2

FDA UNII

  • NC6C26RM46

Other Registry Numbers

  • 116163-63-4
  • 145427-92-5
  • 61356-56-7

System Generated Number

  • 0026934872

Structure Descriptors

InChI

1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20+,21+,22-/m0/s1

InChIKey

PNKLMTPXERFKEN-MLXHEQMXSA-N

Smiles

CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)O)C)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 7220ug/kg (7.22mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Applied and Environmental Microbiology. Vol. 35, Pg. 636, 1978.
guinea pig LD50 oral 500ug/kg (0.5mg/kg) BLOOD: HEMORRHAGE Developments in Food Science. Vol. 4, Pg. 135, 1983.
mouse LD50 intraperitoneal 6500ug/kg (6.5mg/kg)   Agricultural and Biological Chemistry. Vol. 46, Pg. 2613, 1982.
mouse LD50 oral 3800ug/kg (3.8mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 191, 1981.
mouse LD50 subcutaneous 6700ug/kg (6.7mg/kg)   Toxicon. Vol. 24, Pg. 985, 1986.
rat LD50 intracrebral 52ug/kg (0.052mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicon. Vol. 26, Pg. 923, 1988.
rat LD50 subcutaneous 1mg/kg (1mg/kg)   Toxicon. Vol. 26, Pg. 923, 1988.