Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Glibornuride [USAN:INN:BAN]
RN: 26944-48-9
UNII: VP83E7434R
InChIKey: RMTYNAPTNBJHQI-LLDVTBCESA-N

Note

  • An oral, sulfonylurea hypoglycemic agent which stimulates insulin secretion.

Molecular Formula

  • C18-H26-N2-O4-S

Molecular Weight

  • 366.4794
 

Classification Codes

  • Antidiabetic
  • Hypoglycemic Agents
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Glibornuride
  • Glibornuride [USAN:INN:BAN]

Synonyms

  • 1-((1R)-2-endo-Hydroxy-3-endo-bornyl)-3-(p-tolylsulfonyl)urea
  • Benzenesulfonamide, N-(((3-hydroxy-4,7,7-trimethylbicyclo(2.2.1)hept-2-yl)amino)carbonyl)-4-methyl-, (1S-(endo, endo))-
  • BRN 2821299
  • EINECS 248-124-6
  • endo, endo-1-((1R)-(2-Hydroxy-3-bornyl))-3-(p-tolylsulfonyl)urea
  • Glibornurida
  • Glibornurida [INN-Spanish]
  • Glibornuride
  • Glibornuridum
  • Glibornuridum [INN-Latin]
  • Glutril
  • N-(((3-Hydroxy-4,7,7-trimethylbicyclo(2.2.1)hept-2-yl)amino)carbonyl)-4-methylbenzenesulfonamide (1S-(endo,endo))-
  • Ro 6-4563
  • Ro 6-4563/8
  • UNII-VP83E7434R

Systematic Names

  • Benzenesulfonamide, N-(((3-hydroxy-4,7,7-trimethylbicyclo(2.2.1)hept-2-yl)amino)carbonyl)-4-methyl-, (1S-(endo, endo))-
  • Glibornuride
  • Urea, 1-(2-hydroxy-3-bornyl)-3-(p-tolylsulfonyl)-, (1R,2R,3S,4S)-

Registry Numbers

CAS Registry Number

  • 26944-48-9

FDA UNII

  • VP83E7434R

System Generated Number

  • 0026944489

Structure Descriptors

InChI

1S/C18H26N2O4S/c1-11-5-7-12(8-6-11)25(23,24)20-16(22)19-14-13-9-10-18(4,15(14)21)17(13,2)3/h5-8,13-15,21H,9-10H2,1-4H3,(H2,19,20,22)/t13-,14+,15+,18+/m1/s1

InChIKey

RMTYNAPTNBJHQI-LLDVTBCESA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)NC(=O)N[C@H]2[C@H]3CC[C@@]([C@H]2O)(C3(C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1530mg/kg (1530mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.
mouse LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.
mouse LD50 subcutaneous 20gm/kg (20000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.
rat LD50 intraperitoneal 1360mg/kg (1360mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.
rat LD50 oral 18gm/kg (18000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.
rat LD50 subcutaneous 10800mg/kg (10800mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1925, 1972.