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Substance Name: Abbott 40060
RN: 27022-50-0
UNII: RQ6VMJ9R7U
InChIKey: VCCLTMGHQTUHGC-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H6-F3-N3

Molecular Weight

  • 237.183
 
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Names and Synonyms

Name of Substance

  • Abbott 40060

Synonyms

  • 3-(Trifluoromethyl)-1,2,4-triazolo(3,4-a)isoquinoline
  • 3-(Trifluoromethyl)-s-triazolo(3,4-a)isoquinoline
  • Abbott 40060
  • BRN 0615862
  • NC 1140
  • UNII-RQ6VMJ9R7U

Systematic Names

  • 1,2,4-Triazolo(3,4-a)isoquinoline, 3-(trifluoromethyl)- (9CI)
  • 3-Trifluoromethyl-s-triazolo(3,4-a)-isoquinoline
  • s-Triazolo(3,4-a)isoquinoline, 3-(trifluoromethyl)-

Registry Numbers

CAS Registry Number

  • 27022-50-0

FDA UNII

  • RQ6VMJ9R7U

System Generated Number

  • 0027022500

Structure Descriptors

InChI

1S/C11H6F3N3/c12-11(13,14)10-16-15-9-8-4-2-1-3-7(8)5-6-17(9)10/h1-6H

InChIKey

VCCLTMGHQTUHGC-UHFFFAOYSA-N

Smiles

c12n(ccc3ccccc13)c(nn2)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 440mg/kg (440mg/kg)   United States Patent Document. Vol. #3873705,
mouse LD50 oral 720mg/kg (720mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 212, Pg. 205, 1974.
rat LD50 intraperitoneal 487mg/kg (487mg/kg)   United States Patent Document. Vol. #3873705,
rat LD50 oral 660mg/kg (660mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 212, Pg. 205, 1974.