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Substance Name: Oxametacin [INN]
RN: 27035-30-9
UNII: 8G02RSW5CM
InChIKey: AJRNYCDWNITGHF-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H17-Cl-N2-O4

Molecular Weight

  • 372.8063
 
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Names and Synonyms

Name of Substance

  • Oxametacin [INN]
  • Oxametacine
  • Oxamethacin

Synonyms

  • 1-(4-Chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl-1H-indole-3-acetamide
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetohydroxamic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetohydroxamic acid
  • 5-22-05-00243 (Beilstein Handbook Reference)
  • ABC 8/3
  • Acido 1-(p-clorobenzoil)-5-metossi-2-metil-3-indolilacetoidrossamico
  • Acido 1-(p-clorobenzoil)-5-metossi-2-metil-3-indolilacetoidrossamico [Italian]
  • Acido indoxamico
  • Acido indoxamico [Italian]
  • BRN 0497721
  • EINECS 248-179-6
  • Flogar
  • Indoxamic acid
  • Oxametacin
  • Oxametacina
  • Oxametacina [INN-Spanish]
  • Oxametacine
  • Oxametacine [INN-French]
  • Oxametacinum
  • Oxametacinum [INN-Latin]
  • Oxamethacin
  • UNII-8G02RSW5CM

Systematic Names

  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetohydroxamic acid
  • 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl- (9CI)
  • Indole-3-acetohydroxamic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
  • Oxametacin

Registry Numbers

CAS Registry Number

  • 27035-30-9

FDA UNII

  • 8G02RSW5CM

System Generated Number

  • 0027035309

Structure Descriptors

InChI

1S/C19H17ClN2O4/c1-11-15(10-18(23)21-25)16-9-14(26-2)7-8-17(16)22(11)19(24)12-3-5-13(20)6-4-12/h3-9,25H,10H2,1-2H3,(H,21,23)

InChIKey

AJRNYCDWNITGHF-UHFFFAOYSA-N

Smiles

Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)NO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 32mg/kg (32mg/kg)   Bollettino Chimico Farmaceutico. Vol. 114, Pg. 319, 1975.
mouse LD50 oral 92mg/kg (92mg/kg)   Bollettino Chimico Farmaceutico. Vol. 114, Pg. 319, 1975.
rat LD50 intraperitoneal 40mg/kg (40mg/kg)   Bollettino Chimico Farmaceutico. Vol. 114, Pg. 319, 1975.
rat LD50 oral 78mg/kg (78mg/kg)   Bollettino Chimico Farmaceutico. Vol. 114, Pg. 319, 1975.