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Substance Name: Flutazolam [INN:JAN]
RN: 27060-91-9
UNII: 5G2K7O5D8S
InChIKey: WMFSSTNVXWNLKI-UHFFFAOYSA-N

Classification Code

  • Reproductive Effect

Molecular Formula

  • C19-H18-Cl-F-N2-O3

Molecular Weight

  • 376.8132
 
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Names and Synonyms

Name of Substance

  • Flutazolam
  • Flutazolam [INN:JAN]

Synonyms

  • 10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • 10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • BRN 1092501
  • Flutazolam
  • Flutazolamum
  • Flutazolamum [INN-Latin]
  • MS-4101
  • UNII-5G2K7O5D8S

Systematic Names

  • 10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • 10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-

Registry Numbers

CAS Registry Number

  • 27060-91-9

FDA UNII

  • 5G2K7O5D8S

System Generated Number

  • 0027060919

Structure Descriptors

InChI

1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

InChIKey

WMFSSTNVXWNLKI-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)C23c4cc(ccc4N(C(=O)CN2CCO3)CCO)Cl)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1680mg/kg (1680mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
mouse LD50 oral 1910mg/kg (1910mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2335, 1978.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat LD50 intraperitoneal 4050mg/kg (4050mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat LD50 oral > 6gm/kg (6000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat LD50 subcutaneous > 6gm/kg (6000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.