Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Pyran copolymer
RN: 27100-68-1

Note

  • Copolymer of divinyl ether and maleic anhydride that acts as an immunostimulant with antineoplastic and anti-infective properties. It is used in combination with other antineoplastic agents.

Molecular Formula

  • (C4-H6-O.C4-H2-O3)x-

Molecular Weight

  • 168.1472
 

Classification Codes

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Interferon Inducers
* denotes mobile formatted website

Links to Resources

Names and Synonyms

Name of Substance

  • Pyran copolymer

MeSH Heading

  • Pyran copolymer

Synonyms

  • 12768-40-0
  • 2,5-Furandione, polymer with 1,1'-oxybis(ethene)
  • CCRIS 4292
  • Divema
  • Divinyl ether combined with maleic anhydride (1:2)
  • Divinyl ether maleic anhydride copolymer
  • Divinyl ether- maleic anhydride copolymers
  • Divinyl ether- maleic anhydride cyclic copolymer
  • Divinyl ether- maleic anhydride cyclopolymer
  • Divinyl ether- maleic anhydride polymer
  • Maleic anhydride, polymer with vinyl ether
  • Maleic anhydride- vinyl ether copolymer
  • Maleic anhydride- vinyl ether polymer
  • MVE-1
  • MVE-2
  • MVE-4
  • NSC 170347
  • NSC 59196
  • Pyran
  • Pyran (copolymer)
  • Pyran NSC 46015
  • Pyran NSC 46015 D
  • Pyran XA 124-177
  • Vinyl ether combined with maleic anhydride
  • Vinyl ether- maleic anhydride copolymer
  • XA 124-177
  • XA 146-85-2

Systematic Names

  • 2,5-Furandione, polymer with 1,1'-oxybis(ethene) (9CI)
  • Maleic anhydride divinyl ether copolymer
  • Maleic anhydride, polymer with vinyl ether

Registry Numbers

CAS Registry Number

  • 27100-68-1

Other Registry Numbers

  • 12768-38-6
  • 12768-39-7
  • 12768-40-0
  • 64296-42-0
  • 64296-58-8
  • 64296-59-9
  • 74621-32-2

System Generated Number

  • 0027100681

Molecular Formulas

Molecular Formula

  • (C4-H6-O.C4-H2-O3)x-

Molecular Formula Fragments

  • C4-H2-O3
  • C4-H6-O
  • COMPONENT

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 100mg/kg (100mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
mammal (species unspecified) LD50 unreported 120ug/kg (0.12mg/kg)   "Handbook of Cancer Immunology," Waters, H., ed., 5 vols., New York, Garland STPM Press, 1978Vol. 5, Pg. 135, 1978.
mouse LD50 intramuscular > 1gm/kg (1000mg/kg) BLOOD: CHANGES IN SPLEEN

LIVER: OTHER CHANGES
Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
mouse LD50 intraperitoneal > 800mg/kg (800mg/kg)   United States Patent Document. Vol. #3812248,
mouse LD50 intravenous 74mg/kg (74mg/kg)   Polymer. The Chemistry, Physics and Technology of High Polymers. Vol. 18, Pg. 461, 1977.
mouse LD50 intravenous 74mg/kg (74mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Polymer. The Chemistry, Physics and Technology of High Polymers. Vol. 18, Pg. 461, 1977.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
rat LD50 intramuscular > 1gm/kg (1000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
rat LD50 intravenous 48700ug/kg (48.7mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: COMA
Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.
rat LD50 oral > 1gm/kg (1000mg/kg)   Progress in Cancer Research and Therapy. Vol. 16, Pg. 345, 1981.