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Substance Name: Tilidine Hydrochloride [USAN]
RN: 27107-79-5
UNII: 4YI72J28N9
InChIKey: MUWDJVKYGSDUSH-KALLACGZSA-N

Classification Codes

  • Analgesic
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H23-N-O2.Cl-H

Molecular Weight

  • 309.835
 
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Names and Synonyms

Name of Substance

  • Tilidine Hydrochloride [USAN]
  • Tilidine trans-(+-)-

Synonyms

  • (+-)-Ethyl trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate hydrochloride
  • dl-trans,trans-Tildine hydrochloride
  • dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaethylester HCl
  • dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaethylester HCl [German]
  • dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid ethyl ester HCl
  • EINECS 248-226-0
  • Go 1261 C
  • GO-1261
  • Tilidate
  • Tilidine hydrochloride
  • UNII-4YI72J28N9
  • Valoron
  • W 5759A

Systematic Names

  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, hydrochloride (trans)-(+-)-
  • 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, hydrochloride, (1R,2S)-rel-
  • Ethyl trans-(1)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate hydrochloride

Superlist Name

  • DEA No. 9750

Registry Numbers

CAS Registry Number

  • 27107-79-5

FDA UNII

  • 4YI72J28N9

Other Registry Number

  • 35481-00-6

System Generated Number

  • 0027107795

Molecular Formulas

Molecular Formula

  • C17-H23-N-O2.Cl-H

Molecular Formula Fragments

  • C17-H23-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H23NO2.ClH/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3;/h5-8,10-12,15H,4,9,13H2,1-3H3;1H/t15-,17+;/m1./s1

InChIKey

MUWDJVKYGSDUSH-KALLACGZSA-N

Smiles

C1=CCC[C@@](c2ccccc2)([C@@H]1N(C)C)C(=O)OCC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
mouse LD50 intravenous 52mg/kg (52mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
mouse LD50 oral 437mg/kg (437mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
mouse LD50 subcutaneous 490mg/kg (490mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
rat LD50 intravenous 74mg/kg (74mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
rat LD50 oral 418mg/kg (418mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.
rat LD50 subcutaneous 400mg/kg (400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 977, 1970.