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Substance Name: Tramadol [INN:BAN]
RN: 27203-92-5
UNII: 39J1LGJ30J
InChIKey: TVYLLZQTGLZFBW-ZBFHGGJFSA-N

Note

  • A narcotic analgesic proposed for severe pain. It may be habituating.

Molecular Formula

  • C16-H25-N-O2

Molecular Weight

  • 263.3785
 

Classification Codes

  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Results Name

  • Tramadol [INN:BAN]

Name of Substance

  • Tramadol
  • Tramadol [INN:BAN]

MeSH Heading

  • Tramadol

Synonyms

  • (+-)-Tramadol
  • Biomadol
  • CG 315E
  • cis-Tramadol
  • Contramid
  • Cyclohexanol, 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-
  • E 265
  • EINECS 248-319-6
  • HSDB 7047
  • Labesfal
  • Racemic tramadol
  • Ralivia ER
  • Ralivia flashtab
  • Ryzolt
  • Tiparol
  • Tradolan
  • Tradonal odis
  • Tramadis
  • Tramadol
  • Tramadol Contramid
  • Tramadolum
  • Tramadolum [INN-Latin]
  • Tramadon
  • Tramaliv
  • Trapidol
  • U 26255A
  • Ultram
  • UNII-39J1LGJ30J
  • Zytram

Systematic Names

  • Cyclohexanol, 2-((dimethylamino)-1-(3-methoxyphenyl)-, cis-(+-)-
  • Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-
  • Tramadol

Registry Numbers

CAS Registry Number

  • 27203-92-5

FDA UNII

  • 39J1LGJ30J

Other Registry Numbers

  • 113683-92-4
  • 73806-46-9

System Generated Number

  • 0027203925

Structure Descriptors

InChI

1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1

InChIKey

TVYLLZQTGLZFBW-ZBFHGGJFSA-N

Smiles

CN(C)C[C@H]1CCCC[C@@]1(c2cccc(c2)OC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 4032ug/kg (4.032mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Southern Medical Journal. Vol. 90, Pg. 826, 1997.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   European Patent Application. Vol. #0047990,
rat LD50 oral 228mg/kg (228mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 286mg/kg (286mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
women TDLo oral 16mg/kg/4D-I (16mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: EUPHORIA

BEHAVIORAL: WAKEFULNESS
American Journal of Psychiatry. Vol. 154, Pg. 1624, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.010 (none)   EST
Atmospheric OH Rate Constant 1.47E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.