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Substance Name: Colchicine, N-deacetyl-10-thio-
RN: 2731-16-0
InChIKey: NUNCOHUMTCDISK-AWEZNQCLSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C20-H23-N-O4-S

Molecular Weight

  • 373.4707
 
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Names and Synonyms

Synonyms

  • 4-14-00-00954 (Beilstein Handbook Reference)
  • Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)-
  • BRN 2822164
  • Colchicine, N-deacetyl-10-demethoxy-10-methylthio-
  • Colchicine, N-deacetyl-thio-
  • Corps R. 261
  • Deacetylthiocolchicine
  • Desacetyl thiocolchicine
  • N-Deacetyl-10-demethoxy-10-methylthiocolchicine
  • N-Deacetylmethylthiocolchicine
  • N-Deacetylthiocolchicine
  • N-Desacetyl thiocolchicine
  • N-Desacetylthiocolchicine
  • NSC 9170
  • R 261
  • Thio-colciran
  • Thiolcolciran

Systematic Names

  • Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)- (9CI)
  • Colchicine, N-deacetyl-10-thio-

Registry Numbers

CAS Registry Number

  • 2731-16-0

System Generated Number

  • 0002731160

Structure Descriptors

InChI

1S/C20H23NO4S/c1-23-16-9-11-5-7-14(21)13-10-15(22)17(26-4)8-6-12(13)18(11)20(25-3)19(16)24-2/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1

InChIKey

NUNCOHUMTCDISK-AWEZNQCLSA-N

Smiles

COc1cc2CC[C@H](N)C3=CC(=O)C(=CC=C3c2c(OC)c1OC)SC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 71ug/kg/D (0.071mg/kg) BLOOD: LEUKOPENIA

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Bulletin de l'Association Francaise pour l'Etude du Cancer. Vol. 42, Pg. 308, 1955.
mouse LD50 intraperitoneal 66mg/kg (66mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 636, 1981.
mouse LD50 intravenous 80mg/kg (80mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 107, Pg. 150, 1956.
mouse LD50 oral 50mg/kg (50mg/kg)   Bulletin de l'Association Francaise pour l'Etude du Cancer. Vol. 42, Pg. 308, 1955.
rat LD50 intramuscular 37mg/kg (37mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 98, Pg. 479, 1958.
rat LD50 intraperitoneal 175mg/kg (175mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 98, Pg. 479, 1958.
rat LDLo intracrebral 2mg/kg (2mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo parenteral 2000ug/kg (2mg/kg)   Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.