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Substance Name: Dimefline hydrochloride [USAN:JAN]
RN: 2740-04-7
UNII: H0XB4R74ID
InChIKey: RCISIXJGNBXXPZ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Stimulant (Respiratory)

Molecular Formula

  • C20-H21-N-O3.Cl-H

Molecular Weight

  • 359.851
 
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Names and Synonyms

Name of Substance

  • Dimefline hydrochloride
  • Dimefline hydrochloride [USAN:JAN]

Synonyms

  • 3-Methyl-7-methoxy-8-(dimethylamino-methyl)-flavone hydrochloride
  • 4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-, hydrochloride
  • 8-((Dimethylamino)methyl)-7-methoxy-3-methylflavone hydrochloride
  • Dimefline HCl
  • Dimefline hydrochloride
  • DW 62
  • DW-62
  • EINECS 220-366-7
  • NSC 114650
  • NSC-114650
  • REC 7-0267
  • REC 7/0267
  • Remeflin
  • Remeflin (VAN)
  • Remefline
  • UNII-H0XB4R74ID

Systematic Names

  • 4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-, hydrochloride
  • 8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4-benzopyrone hydrochloride
  • Flavone, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 2740-04-7

FDA UNII

  • H0XB4R74ID

Related Registry Number

  • 1165-48-6 (Parent)

System Generated Number

  • 0002740047

Molecular Formulas

Molecular Formula

  • C20-H21-N-O3.Cl-H

Molecular Formula Fragments

  • C20-H21-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H21NO3.ClH/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14;/h5-11H,12H2,1-4H3;1H

InChIKey

RCISIXJGNBXXPZ-UHFFFAOYSA-N

Smiles

c12c(c(ccc1c(c(C)c(o2)c1ccccc1)=O)OC)C[NH+](C)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 5mg/kg (5mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.
mouse LD50 intravenous 1480ug/kg (1.48mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 263, 1964.
mouse LD50 oral 12mg/kg (12mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.
mouse LD50 subcutaneous 4mg/kg (4mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.
rat LD50 intravenous 2mg/kg (2mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1239, 1982.
rat LD50 oral 14mg/kg (14mg/kg)   Drugs in Japan Vol. 6, Pg. 345, 1982.