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Substance Name: Oxdralazine dihydrochloride
RN: 27464-23-9
UNII: 483KXL2L9D
InChIKey: UKFTXWKNVSVVCJ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C8-H15-N5-O2.2Cl-H

Molecular Weight

  • 286.1613
 
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Names and Synonyms

Name of Substance

  • Oxdralazine dihydrochloride

Synonyms

  • 3-(Bis(2-hydroxyethyl)amino)-6-hydrazinopyridazine dihydrochloride
  • 3-Hydrazino-6-(N,N-bis-(2-hydroxyethyl)amino)pyridazine dihydrochloride
  • 3-Idrazino-6-(N,N-bis-(2-idrossietil)-amino)-piridazina cloridrato
  • 3-Idrazino-6-(N,N-bis-(2-idrossietil)-amino)-piridazina cloridrato [Italian]
  • L 6150
  • NSC 298268
  • Oxdralazine
  • UNII-483KXL2L9D

Systematic Name

  • Pyridazine, 3-(bis(2-hydroxyethyl)amino)-6-hydrazino-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 27464-23-9

FDA UNII

  • 483KXL2L9D

Related Registry Number

  • 17259-75-5 (Parent)

System Generated Number

  • 0027464239

Molecular Formulas

Molecular Formula

  • C8-H15-N5-O2.2Cl-H

Molecular Formula Fragments

  • C8-H15-N5-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C8H15N5O2.2ClH/c9-10-7-1-2-8(12-11-7)13(3-5-14)4-6-15;;/h1-2,14-15H,3-6,9H2,(H,10,11);2*1H

InChIKey

UKFTXWKNVSVVCJ-UHFFFAOYSA-N

Smiles

c\1cc(n[nH]/c1=N\N)N(CCO)CCO.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 75mg/kg (75mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973.
dog LD50 oral 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973.
guinea pig LD50 oral 188mg/kg (188mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972.
human TDLo intravenous 29ug/kg (0.029mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Drugs of the Future. Vol. 2, Pg. 172, 1977.
mouse LD50 intraperitoneal 263mg/kg (263mg/kg)   Drugs of the Future. Vol. 2, Pg. 172, 1977.
mouse LD50 oral 1520mg/kg (1520mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972.
rabbit LD50 oral 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973.
rat LD50 intraperitoneal 335mg/kg (335mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972.
rat LD50 oral 1800mg/kg (1800mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972.