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Substance Name: Suxibuzone [INN:BAN:JAN]
RN: 27470-51-5
UNII: 86TDZ5WP2B
InChIKey: ONWXNHPOAGOMTG-UHFFFAOYSA-N

Molecular Formula

  • C24-H26-N2-O6

Molecular Weight

  • 438.4774
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Suxibuzone
  • Suxibuzone [INN:BAN:JAN]

Synonyms

  • 3-((4-Butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methoxycarbonyl)propionsaeure
  • 4-Butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione
  • 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate
  • 4-Hydroxymethylbutazolidine hemisuccinate
  • AE 17
  • AE-17
  • Aflogan
  • Alfide
  • BRN 0904563
  • Calibene
  • Danilon
  • EINECS 248-477-6
  • Flamilon
  • Flogos
  • Solurol
  • Suxibuzona
  • Suxibuzona [INN-Spanish]
  • Suxibuzone
  • Suxibuzonum
  • Suxibuzonum [INN-Latin]
  • UNII-86TDZ5WP2B

Systematic Names

  • 3,5-Pyrazolidinedione, 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-, hydrogen succinate (ester)
  • 4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)
  • Butanedioic acid, mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl) ester (9CI)
  • Succinic acid, monoester with 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione
  • Suxibuzone

Registry Numbers

CAS Registry Number

  • 27470-51-5

FDA UNII

  • 86TDZ5WP2B

System Generated Number

  • 0027470515

Structure Descriptors

InChI

1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)

InChIKey

ONWXNHPOAGOMTG-UHFFFAOYSA-N

Smiles

CCCCC1(C(=O)N(N(C1=O)c2ccccc2)c3ccccc3)COC(=O)CCC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 373mg/kg (373mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
mouse LD50 intravenous 285mg/kg (285mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
mouse LD50 oral 1200mg/kg (1200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
mouse LD50 subcutaneous 520mg/kg (520mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rabbit LD50 oral 1266mg/kg (1266mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
rat LD50 intravenous 305mg/kg (305mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat LD50 oral 1700mg/kg (1700mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat LD50 subcutaneous 410mg/kg (410mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.