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Substance Name: Azosemide [USAN:INN:JAN]
RN: 27589-33-9
UNII: MR40VT1L8Z
InChIKey: HMEDEBAJARCKCT-UHFFFAOYSA-N

Classification Codes

  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Natriuretic Agents
  • Reproductive Effect

Molecular Formula

  • C12-H11-Cl-N6-O2-S2

Molecular Weight

  • 370.8439
 
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Names and Synonyms

Name of Substance

  • Azosemide
  • Azosemide [USAN:INN:JAN]

Synonyms

  • 2-Chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenylsulfanilamide
  • 5-(4'-Chloro-5'-sulfamoyl-2'-thenylaminophenyl)-tetrazole
  • Azosemida
  • Azosemida [INN-Spanish]
  • Azosemide
  • Azosemidum
  • Azosemidum [INN-Latin]
  • Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-
  • BRN 1178491
  • EINECS 248-549-7
  • PLE 1053
  • SK-110
  • UNII-MR40VT1L8Z

Systematic Names

  • Azosemide
  • Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-
  • Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenyl-

Registry Numbers

CAS Registry Number

  • 27589-33-9

FDA UNII

  • MR40VT1L8Z

System Generated Number

  • 0027589339

Structure Descriptors

InChI

InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

InChIKey

HMEDEBAJARCKCT-UHFFFAOYSA-N

Smiles

NS(=O)(=O)c1cc(c(NCc2cccs2)cc1Cl)c3nnn[nH]3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 562mg/kg (562mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
mouse LD50 intravenous 138mg/kg (138mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
mouse LD50 oral 6350mg/kg (6350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
mouse LD50 subcutaneous 762mg/kg (762mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rabbit LD50 intravenous 130mg/kg (130mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rabbit LD50 oral 282mg/kg (282mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 intraperitoneal 287mg/kg (287mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 intravenous 252mg/kg (252mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 oral 2545mg/kg (2545mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 subcutaneous 589mg/kg (589mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 219.5 deg C   EXP
log P (octanol-water) 0.060 (none)   EST
Atmospheric OH Rate Constant 3.71E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.