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Substance Name: Tilorone hydrochloride [USAN]
RN: 27591-69-1
UNII: BJ507J4LKY
InChIKey: BSVYJQAWONIOOU-UHFFFAOYSA-N

Note

  • An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.

Molecular Formula

  • C25-H34-N2-O3.2Cl-H

Molecular Weight

  • 483.476
 

Classification Codes

  • Antiviral
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Tilorone hydrochloride
  • Tilorone hydrochloride [USAN]

Synonyms

  • 2,7-Bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride
  • 2,7-Bis-DEAE-fluorenone
  • 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride
  • Bis-DEAE-fluorenone
  • Bis-deae-fluorenone hydrochloride
  • DEAE-F
  • NSC-143969
  • RMI 10008DA
  • Tilorone
  • Tilorone dihydrochloride
  • Tilorone HCl
  • Tilorone hydrochloride
  • UNII-BJ507J4LKY

Systematic Names

  • 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride
  • Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 27591-69-1

FDA UNII

  • BJ507J4LKY

Other Registry Numbers

  • 33562-94-6
  • 93968-77-5

Related Registry Number

  • 27591-97-5 (Parent)

System Generated Number

  • 0027591691

Molecular Formulas

Molecular Formula

  • C25-H34-N2-O3.2Cl-H

Molecular Formula Fragments

  • C25-H34-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H

InChIKey

BSVYJQAWONIOOU-UHFFFAOYSA-N

Smiles

c12c3ccc(cc3C(c1cc(OCCN(CC)CC)cc2)=O)OCCN(CC)CC.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 4mg/kg (4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 209, 1973.
mouse LD50 intraperitoneal 145mg/kg (145mg/kg)   Science. Vol. 169, Pg. 1213, 1970.
mouse LD50 intravenous 53500ug/kg (53.5mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 20, 1983.
mouse LD50 oral 800mg/kg (800mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 20, 1983.
rat LD50 intraperitoneal 244mg/kg (244mg/kg)   Science. Vol. 169, Pg. 1213, 1970.
rat LD50 oral 852mg/kg (852mg/kg)   Science. Vol. 169, Pg. 1213, 1970.