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Substance Name: Tilorone [INN]
RN: 27591-97-5
UNII: O6W7VEW6KS
InChIKey: MPMFCABZENCRHV-UHFFFAOYSA-N

Note

  • An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.

Molecular Formula

  • C25-H34-N2-O3

Molecular Weight

  • 410.555
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Interferon Inducers
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Tilorone
  • Tilorone [INN]

MeSH Heading

  • Tilorone

Synonyms

  • 2,7-Bis(2-(diethylamino)ethoxy)-9H-fluoren-9-one
  • Bis-DEAE-fluorenone
  • BRN 2011558
  • Tilorona
  • Tilorona [INN-Spanish]
  • Tilorone
  • Tiloronum
  • Tiloronum [INN-Latin]
  • UNII-O6W7VEW6KS

Systematic Name

  • 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-

Registry Numbers

CAS Registry Number

  • 27591-97-5

FDA UNII

  • O6W7VEW6KS

Related Registry Number

  • 27591-69-1 (di-hydrochloride)

System Generated Number

  • 0027591975

Structure Descriptors

InChI

1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3

InChIKey

MPMFCABZENCRHV-UHFFFAOYSA-N

Smiles

c12c3c(cc(OCCN(CC)CC)cc3)C(c1cc(OCCN(CC)CC)cc2)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 121mg/kg (121mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 102, 1972.
mouse LD50 oral 1780mg/kg (1780mg/kg)   Pharmaceutical Chemistry Journal Vol. 23, Pg. 497, 1989.
mouse LD50 unreported 200mg/kg (200mg/kg)   Pharmaceutical Chemistry Journal Vol. 12, Pg. 1460, 1978.
mouse LD50 unreported 200mg/kg (200mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE Pharmaceutical Chemistry Journal Vol. 12, Pg. 1460, 1978.