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Substance Name: Probenazole
RN: 27605-76-1
InChIKey: WHHIPMZEDGBUCC-UHFFFAOYSA-N

Note

  • Induces disease resistance against rice blast fungus in rice.

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative

Molecular Formula

  • C10-H9-N-O3-S

Molecular Weight

  • 223.251
 
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Names and Synonyms

Results Name

  • Probenazole

Name of Substance

  • Oryzemate
  • Probenazole

Synonyms

  • 3-(2-Propenyloxy)-1,2-benzisothiazole 1,1-dioxide
  • 3-(Allyloxy)-1,2-benzisothiazole 1,1-dioxide
  • BRN 1214464
  • Oryzaemate
  • Oryzemate
  • PO-20
  • Probenazole

Systematic Names

  • 1,2-Benzisothiazole, 3-(2-propenyloxy)-, 1,1-dioxide (9CI)
  • 1,2-Benzisothiazole, 3-(allyloxy)-, 1,1-dioxide

Registry Numbers

CAS Registry Number

  • 27605-76-1

System Generated Number

  • 0027605761

Structure Descriptors

InChI

1S/C10H9NO3S/c1-2-7-14-10-8-5-3-4-6-9(8)15(12,13)11-10/h2-6H,1,7H2

InChIKey

WHHIPMZEDGBUCC-UHFFFAOYSA-N

Smiles

C=CCOC1=NS(=O)(=O)c2ccccc12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 745mg/kg (745mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 205, 1977.
mouse LD50 oral 2750mg/kg (2750mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 205, 1977.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Japan Pesticide Information. Vol. (37), Pg. 37, 1980.
rat LD50 intraperitoneal 850mg/kg (850mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 219, 1977.
rat LD50 oral 2030mg/kg (2030mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 7, Pg. 307, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Japan Pesticide Information. Vol. (37), Pg. 37, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 138.5 deg C   EXP
log P (octanol-water) 1.4 (none)   EXP
Water Solubility 150 mg/L   EXP
Vapor Pressure 1.15E-05 mm Hg 25 EST
Henry's Law Constant 1.52E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.29E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.