Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Muscimol
RN: 2763-96-4
UNII: D5M179TY2E
InChIKey: ZJQHPWUVQPJPQT-UHFFFAOYSA-N

Note

  • A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.

Molecular Formula

  • C4-H6-N2-O2

Molecular Weight

  • 114.1034
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Agonists
  • GABA-A Receptor Agonists
  • Human Data
  • Neurotransmitter Agents

Superlist Classification Codes

  • Reportable Quantity (RQ) = 1000 lb
  • Threshold Planning Quantity (TPQ) = 500/10000 lb
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Muscimol

MeSH Heading

  • Muscimol

Synonyms

  • 3(2H)-Isoxazolone, 5-(aminomethyl)-
  • 3-Hydroxy-5-aminomethylisoxazole
  • 3-Hydroxy-5-aminomethylisoxazole-agarin
  • 3-Isoxazolol, 5-(aminomethyl)-
  • 5-(Aminomethyl)-3(2H)-isoxazolone
  • 5-(Aminomethyl)-3-isoxazolol
  • 5-Aminomethyl-3-hydroxyisoxazole
  • 5-Aminomethyl-3-isoxyzole
  • Agarin
  • Agarine
  • CCRIS 3720
  • EINECS 220-430-4
  • HSDB 6036
  • Muscimol
  • NSC 333569
  • Pantherin
  • Pantherine
  • RCRA waste number P007
  • UNII-D5M179TY2E

Systematic Names

  • 3(2H)-Isoxazolone, 5-(aminomethyl)-
  • 3-Isoxazolol, 5-(aminomethyl)-
  • 5-(Aminomethyl)isoxazol-3-ol hydrate
  • Muscimol

Superlist Names

  • 3(2H)-Isoxazolone, 5-(aminomethyl)-
  • 5-(Aminomethyl)-3-isoxazolol
  • Muscimol
  • RCRA waste no. P007

Registry Numbers

CAS Registry Number

  • 2763-96-4

FDA UNII

  • D5M179TY2E

Other Registry Number

  • 2489-10-3

System Generated Number

  • 0002763964

Structure Descriptors

InChI

1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

InChIKey

ZJQHPWUVQPJPQT-UHFFFAOYSA-N

Smiles

c1(cc(no1)O)CN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 109ug/kg (0.109mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.
mouse LD50 intraperitoneal 2500ug/kg (2.5mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.
mouse LD50 intravenous 5620ug/kg (5.62mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11824,
mouse LD50 oral 22mg/kg (22mg/kg)   European Patent Application. Vol. #0000338,
mouse LD50 subcutaneous 3800ug/kg (3.8mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.
rabbit LDLo intravenous 10mg/kg (10mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.
rat LD50 intravenous 4500ug/kg (4.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.
rat LD50 oral 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 311, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 175 deg C   EXP
log P (octanol-water) -2.39E+00 (none)   EXP
Water Solubility 5.67E+05 mg/L 25 EST
Vapor Pressure 2.94E-04 mm Hg 25 EST
Henry's Law Constant 1.61E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.56E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.