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Substance Name: Loxapine succinate [USAN:USP]
RN: 27833-64-3
UNII: X59SG0MRYU
InChIKey: YQZBAXDVDZTKEQ-UHFFFAOYSA-N

Note

  • An antipsychotic agent used in schizophrenia.

Molecular Formula

  • C18-H18-Cl-N3-O.C4-H6-O4

Molecular Weight

  • 445.9006
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Loxapine succinate [USAN:USP]

MeSH Heading

  • Loxapine

Synonyms

  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine succinate (1:1)
  • Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
  • CCRIS 1917
  • CL 71563
  • Daxolin
  • EINECS 248-682-0
  • Lederle
  • Loxapac
  • Loxapine
  • Loxapine succinate
  • Loxitane
  • UNII-X59SG0MRYU

Systematic Names

  • Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
  • Cloxazepin
  • Succinic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
  • Succinic acid, compound with 2-chloro-11-(4-methylpiperazin-1-yl)dibenz(b,f)(1,4)oxazepine (1:1)

Registry Numbers

CAS Registry Number

  • 27833-64-3

FDA UNII

  • X59SG0MRYU

Related Registry Number

  • 1977-10-2 (Parent)

System Generated Number

  • 0027833643

Molecular Formulas

Molecular Formula

  • C18-H18-Cl-N3-O.C4-H6-O4

Molecular Formula Fragments

  • C18-H18-Cl-N3-O
  • C4-H6-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)

InChIKey

YQZBAXDVDZTKEQ-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24.OC(=O)CCC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women LDLo oral 30mg/kg (30mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Clinical Toxicology. Vol. 14, Pg. 181, 1979.
women TDLo oral 6mg/kg/2D-I (6mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Journal of Clinical Psychiatry. Vol. 44, Pg. 37, 1983.
women TDLo oral 27mg/kg/9D-I (27mg/kg) ENDOCRINE: HYPERGLYCEMIA Journal of Clinical Psychiatry. Vol. 44, Pg. 347, 1983.