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Substance Name: Loxapine succinate [USAN:USP]
RN: 27833-64-3
UNII: X59SG0MRYU
InChIKey: YQZBAXDVDZTKEQ-UHFFFAOYSA-N
Note
- An antipsychotic agent used in schizophrenia.
Molecular Formula
- C18-H18-Cl-N3-O.C4-H6-O4
Molecular Weight
- 445.9006
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antipsychotic
- Drug / Therapeutic Agent
- Human Data
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Names and Synonyms
Name of Substance
- Loxapine succinate [USAN:USP]
MeSH Heading
- Loxapine
Synonyms
- 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine succinate (1:1)
- Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
- CCRIS 1917
- CL 71563
- Daxolin
- EINECS 248-682-0
- Lederle
- Loxapac
- Loxapine
- Loxapine succinate
- Loxitane
- UNII-X59SG0MRYU
Systematic Names
- Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
- Cloxazepin
- Succinic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine (1:1)
- Succinic acid, compound with 2-chloro-11-(4-methylpiperazin-1-yl)dibenz(b,f)(1,4)oxazepine (1:1)
Registry Numbers
CAS Registry Number
- 27833-64-3
FDA UNII
- X59SG0MRYU
Related Registry Number
- 1977-10-2 (Parent)
System Generated Number
- 0027833643
Molecular Formulas
Molecular Formula
- C18-H18-Cl-N3-O.C4-H6-O4
Molecular Formula Fragments
- C18-H18-Cl-N3-O
- C4-H6-O4
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)InChIKey
YQZBAXDVDZTKEQ-UHFFFAOYSA-NSmiles
CN1CCN(CC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
women | LDLo | oral | 30mg/kg (30mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Clinical Toxicology. Vol. 14, Pg. 181, 1979. |
women | TDLo | oral | 6mg/kg/2D-I (6mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Journal of Clinical Psychiatry. Vol. 44, Pg. 37, 1983. |
women | TDLo | oral | 27mg/kg/9D-I (27mg/kg) | ENDOCRINE: HYPERGLYCEMIA | Journal of Clinical Psychiatry. Vol. 44, Pg. 347, 1983. |