Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Hydroxyphenytoin
RN: 2784-27-2
InChIKey: XEEDURHPFVXALT-UHFFFAOYSA-N

Note

  • Main metabolite of diphenylhydantoin; reduces Na(+) inhibition at high Na:K ratios.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C15-H12-N2-O3

Molecular Weight

  • 268.2708
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Hydroxyphenytoin

Synonyms

  • (+-)-5-(4-Hydroxyphenyl)-5-phenylhydantoin
  • (Hydroxyphenyl)phenylhydantoin
  • (p-Hydroxyphenyl)phenylhydantoin
  • 2,4-Imidazolidinedione, 5-(4-hydroxyphenyl)-5-phenyl-
  • 4-Hydroxydiphenylhydantoin
  • 4-Hydroxyphenytoin
  • 5-(4'-Hydroxyphenyl)-5-phenylhydantoin
  • 5-(4-Hydroxyphenyl)-5-phenyl hydantoin
  • 5-(4-Hydroxyphenyl)-5-phenyl-2,4-imidazolidinedione
  • 5-(p-Hydroxyphenyl)-5-phenylhydantoin
  • CCRIS 7051
  • dl-5-(p-Hydroxyphenyl)-5-phenylhydantoin
  • EINECS 220-492-2
  • HPPH
  • Hydroxydiphenylhydantoin
  • NSC 156081
  • p-Hydroxydiphenylhydantoin
  • p-Hydroxyphenytoin
  • para-Hydroxyphenytoin

Systematic Names

  • 2,4-Imidazolidinedione, 5-(4-hydroxyphenyl)-5-phenyl- (9CI)
  • 5-(4-Hydroxyphenyl)-5-phenyl-2,4-imidazolidinedione
  • 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione
  • 5-(p-Hydroxyphenyl)-5-phenylhydantoin
  • Hydantoin, 5-(p-hydroxyphenyl)-5-phenyl-

Registry Numbers

CAS Registry Number

  • 2784-27-2

Other Registry Number

  • 57464-82-1

System Generated Number

  • 0002784272

Structure Descriptors

InChI

1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)

InChIKey

XEEDURHPFVXALT-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C2(C(=O)NC(=O)N2)c3ccc(cc3)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,
mouse LD50 oral > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,
rat LD50 oral > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   European Patent Application. Vol. #0006407,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.7 (none)   EXP
Water Solubility 2510 mg/L 25 EST
Vapor Pressure 1.01E-12 mm Hg 25 EST
Henry's Law Constant 1.06E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.64E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.