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Substance Name: Ephedrine, thio-, hydrochloride, L-erythro-
RN: 2784-28-3
InChIKey: WRDBTVCAPYYJDC-GNAZCLTHSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H15-N-S.Cl-H

Molecular Weight

  • 217.762
 
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Names and Synonyms

Synonyms

  • 1-Propanethiol, 2-(methylamino)-1-phenyl-, hydrochloride
  • Benzenemethanethiol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (R-(R*,S*))-
  • S-Ephedrine hydrochloride

Systematic Name

  • Ephedrine, thio-, hydrochloride, L-erythro-

Registry Numbers

CAS Registry Number

  • 2784-28-3

System Generated Number

  • 0002784283

Molecular Formulas

Molecular Formula

  • C10-H15-N-S.Cl-H

Molecular Formula Fragments

  • C10-H15-N-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15NS.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1

InChIKey

WRDBTVCAPYYJDC-GNAZCLTHSA-N

Smiles

c1(ccccc1)[C@H]([C@@H](NC)C)S.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 58mg/kg (58mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
guinea pig LD50 subcutaneous 259mg/kg (259mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
mouse LD50 intraperitoneal 109mg/kg (109mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
mouse LD50 intravenous 78mg/kg (78mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
mouse LD50 oral 410mg/kg (410mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
mouse LD50 subcutaneous 173mg/kg (173mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.