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Substance Name: Isosteviol
RN: 27975-19-5
UNII: 091QB7QO95
InChIKey: KFVUFODCZDRVSS-XGBBNYNSSA-N

Note

  • An antihyperglycemic agent; obtained by acid hydrolysis of stevioside.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H30-O3

Molecular Weight

  • 318.454
 
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Names and Synonyms

Results Name

  • Isosteviol

Name of Substance

  • Isosteviol

Synonyms

  • (4-alpha,8-beta,13-beta)-13-Methyl-16-oxo-17-norkauran-18-oic acid
  • 17-Nor-8-beta,13-beta-kauran-18-oic acid, 13-methyl-16-oxo-
  • CCRIS 6121
  • Isosteviol
  • NSC 231875
  • UNII-091QB7QO95

Systematic Names

  • 17-Norkauran-18-oic acid, 13-methyl-16-oxo-, (4-alpha,8-beta,13-beta)-
  • Isosteviol

Registry Numbers

CAS Registry Number

  • 27975-19-5

FDA UNII

  • 091QB7QO95

System Generated Number

  • 0027975195

Structure Descriptors

InChI

1S/C20H30O3/c1-17-9-5-14-18(2)7-4-8-19(3,16(22)23)13(18)6-10-20(14,12-17)11-15(17)21/h13-14H,4-12H2,1-3H3,(H,22,23)/t13-,14-,17-,18+,19+,20-/m0/s1

InChIKey

KFVUFODCZDRVSS-XGBBNYNSSA-N

Smiles

C1[C@@H]2[C@@]3(CC([C@](C1)(C)C3)=O)CC[C@H]1[C@@]2(CCC[C@@]1(C)C(=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1070mg/kg (1070mg/kg) LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.
mouse LD50 intravenous 612mg/kg (612mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.
mouse LDLo oral 5060mg/kg (5060mg/kg)   Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.
rat LD50 intraperitoneal 671mg/kg (671mg/kg) LIVER: OTHER CHANGES

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.
rat LD50 intravenous 503mg/kg (503mg/kg) LIVER: OTHER CHANGES

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.
rat LDLo oral 3160mg/kg (3160mg/kg)   Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 8, Pg. 33, 1994.