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Substance Name: Sulbenicillin disodium
RN: 28002-18-8
InChIKey: FWRNIJIOFYDBES-HCIBPFAFSA-L

Note

  • Semisynthetic penicillin-type antibiotic.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formulas

  • C16-H16-N2-O7-S2.2Na
  • C16-H18-N2-O7-S2.2Na

Molecular Weight

  • 458.4214
 
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Names and Synonyms

Results Name

  • Sulbenicillin disodium

Synonyms

  • alpha-Sulfobenzylpenicillin disodium
  • Disodium sulbenicillin
  • Disodium sulfobenzylpenicillin
  • EINECS 248-769-3
  • Kedacillin
  • Lilacillin
  • Sulbenicillin disodium
  • Sulfobenzylpenicillin
  • Sulfocillin
  • Sulpelin

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt
  • Disodium (2S-(2alpha,5alpha,6beta))-3,3-dimethyl-7-oxo-6-(phenylsulphonatoacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate

Registry Numbers

CAS Registry Number

  • 28002-18-8

System Generated Number

  • 0028002188

Molecular Formulas

Molecular Formulas

  • C16-H16-N2-O7-S2.2Na
  • C16-H18-N2-O7-S2.2Na

Molecular Formula Fragments

  • C16-H16-N2-O7-S2
  • C16-H18-N2-O7-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C16H18N2O7S2.2Na/c1-16(2)11(15(21)22)18-13(20)9(14(18)26-16)17-12(19)10(27(23,24)25)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,17,19)(H,21,22)(H,23,24,25);;/q;2*+1/p-2/t9-,10?,11+,14-;;/m1../s1

InChIKey

FWRNIJIOFYDBES-HCIBPFAFSA-L

Smiles

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(c3ccccc3)S(=O)(=O)[O-])C(=O)[O-])C.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous 15gm/kg (15000mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 34, Pg. 405, 1975.
mouse LD50 intramuscular 10500mg/kg (10500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
mouse LD50 intraperitoneal 9600mg/kg (9600mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
mouse LD50 intravenous 7900mg/kg (7900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
mouse LD50 oral > 15gm/kg (15000mg/kg)   Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 322, 1971.
mouse LD50 subcutaneous 11500mg/kg (11500mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
rat LD50 intramuscular 8300mg/kg (8300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
rat LD50 intraperitoneal 7200mg/kg (7200mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
rat LD50 intravenous 6gm/kg (6000mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.
rat LD50 oral > 15gm/kg (15000mg/kg)   Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 322, 1971.
rat LD50 subcutaneous 11gm/kg (11000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 262, 1971.