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Substance Name: Megalomicin [INN]
RN: 28022-11-9
UNII: TJB59Q46Z0
InChIKey: LRWRQTMTYVZKQW-WWDNQWNISA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C44-H80-N2-O15

Molecular Weight

  • 877.115
 
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Names and Synonyms

Results Name

  • Megalomicin [INN]

Name of Substance

  • Megalomicin A
  • Megalomicin [INN]

Synonyms

  • Antibiotic W-847-A
  • Antibiotic XK 41C
  • Megalomicin
  • Megalomicina
  • Megalomicina [INN-Spanish]
  • Megalomicine
  • Megalomicine [INN-French]
  • Megalomicinum
  • Megalomicinum [INN-Latin]
  • Megalomycin-A
  • UNII-TJB59Q46Z0

Systematic Name

  • Megalomicin A

Registry Numbers

CAS Registry Number

  • 28022-11-9

FDA UNII

  • TJB59Q46Z0

System Generated Number

  • 0028022119

Structure Descriptors

InChI

1S/C44H80N2O15/c1-16-30-44(11,54)37(50)23(4)33(47)21(2)19-43(10,61-31-18-29(46(14)15)34(48)26(7)56-31)39(60-41-35(49)28(45(12)13)17-22(3)55-41)24(5)36(25(6)40(52)58-30)59-32-20-42(9,53)38(51)27(8)57-32/h21-32,34-39,41,48-51,53-54H,16-20H2,1-15H3/t21-,22-,23+,24+,25-,26+,27+,28+,29-,30-,31+,32+,34+,35-,36+,37-,38+,39-,41+,42-,43-,44-/m1/s1

InChIKey

LRWRQTMTYVZKQW-WWDNQWNISA-N

Smiles

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)O[C@H]4C[C@H]([C@@H](O)[C@H](C)O4)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 350mg/kg (350mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 641, 1972.
mouse LD50 oral 7500mg/kg (7500mg/kg)   Journal of Antibiotics. Vol. 22, Pg. 253, 1969.
mouse LD50 subcutaneous 7gm/kg (7000mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 641, 1972.