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Substance Name: Clocarpramine dihydrochloride
RN: 28058-62-0
UNII: K7UMH49J6Q
InChIKey: UUTRFZNTTSPNOY-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C28-H37-Cl-N4-O.2Cl-H

Molecular Weight

  • 554.0021
 
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Names and Synonyms

Results Name

  • Clocarpramine dihydrochloride

Name of Substance

  • Clocapramine hydrochloride [JAN]

Synonyms

  • 3-Chlorocarpipramine dihydrochloride
  • Clocapramine hydrochloride
  • Clocarpramine dihydrochloride
  • Clocarpramine HCl
  • Clofekton
  • EINECS 248-805-8
  • UNII-K7UMH49J6Q

Systematic Names

  • (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(10,11-dihydro-3-chloro-5H-dibenz(b,f)azepin-5-yl)propyl)-, dihydrochloride
  • 1'-(3-(3-Chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)(1,4'-bipiperidine)-4'-carboxamide dihydrochloride

Registry Numbers

CAS Registry Number

  • 28058-62-0

FDA UNII

  • K7UMH49J6Q

Related Registry Number

  • 47739-98-0 (Parent)

System Generated Number

  • 0028058620

Molecular Formulas

Molecular Formula

  • C28-H37-Cl-N4-O.2Cl-H

Molecular Formula Fragments

  • C28-H37-Cl-N4-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C28H37ClN4O.2ClH/c29-24-12-11-23-10-9-22-7-2-3-8-25(22)33(26(23)21-24)18-6-15-31-19-13-28(14-20-31,27(30)34)32-16-4-1-5-17-32;;/h2-3,7-8,11-12,21H,1,4-6,9-10,13-20H2,(H2,30,34);2*1H

InChIKey

UUTRFZNTTSPNOY-UHFFFAOYSA-N

Smiles

Cl.Cl.NC(=O)C1(CCN(CCCN2c3ccccc3CCc4ccc(Cl)cc24)CC1)N5CCCCC5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
mouse LD50 oral 2550mg/kg (2550mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
mouse LD50 subcutaneous 6500mg/kg (6500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat LD50 intraperitoneal 125mg/kg (125mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat LD50 oral 6800mg/kg (6800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat LD50 subcutaneous > 20gm/kg (20000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.