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Substance Name: Baclofen hydrochloride
RN: 28311-31-1
UNII: 64OSE3996V
InChIKey: WMNUVYYLMCMHLU-UHFFFAOYSA-N

Note

  • A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Molecular Formula

  • C10-H12-Cl-N-O2.Cl-H

Molecular Weight

  • 250.1237
 
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Names and Synonyms

Name of Substance

  • Baclofen hydrochloride

Synonyms

  • 4-Amino-3-(4-chlorophenyl)butyric acid hydrochloride
  • Baclofen HCl
  • Baclofen hydrochloride
  • UNII-64OSE3996V

Registry Numbers

CAS Registry Number

  • 28311-31-1

FDA UNII

  • 64OSE3996V

Other Registry Number

  • 70206-22-3

System Generated Number

  • 0028311311

Structure Descriptors

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H

InChIKey

WMNUVYYLMCMHLU-UHFFFAOYSA-N

Smiles

c1cc(ccc1C(CC(=O)O)CN)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 122mg/kg (122mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 187, 1980.