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Substance Name: Rucaparib [USAN:INN]
RN: 283173-50-2
UNII: 8237F3U7EH
InChIKey: HMABYWSNWIZPAG-UHFFFAOYSA-N

Note

  • NCI: A tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. (NCI Thesaurus)

Molecular Weight

  • 323.3692
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Rucaparib [USAN:INN]

Synonyms

  • 6H-Azepino(5,4,3-cd)indol-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-
  • 6H-Pyrrolo(4,3,2-ef)(2)benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-
  • 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one
  • AG-14447
  • Rubraca
  • Rucaparib
  • UNII-8237F3U7EH

Registry Numbers

CAS Registry Number

  • 283173-50-2

FDA UNII

  • 8237F3U7EH

System Generated Number

  • 0283173502

Structure Descriptors

InChI

1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)

InChIKey

HMABYWSNWIZPAG-UHFFFAOYSA-N

Smiles

CNCc1ccc(cc1)c2[nH]c3cc(F)cc4C(=O)NCCc2c34