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Substance Name: Rucaparib [USAN:INN]
RN: 283173-50-2
UNII: 8237F3U7EH
InChIKey: HMABYWSNWIZPAG-UHFFFAOYSA-N
Note
- NCI: A tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. (NCI Thesaurus)
Molecular Weight
- 323.3692
Classification Codes
- Antineoplastic Agents
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- Treatment of Cancer
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Names and Synonyms
Name of Substance
- Rucaparib [USAN:INN]
Synonyms
- 6H-Azepino(5,4,3-cd)indol-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-
- 6H-Pyrrolo(4,3,2-ef)(2)benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-
- 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one
- AG-14447
- Rubraca
- Rucaparib
- UNII-8237F3U7EH
Registry Numbers
CAS Registry Number
- 283173-50-2
FDA UNII
- 8237F3U7EH
System Generated Number
- 0283173502