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Substance Name: Sorafenib [USAN:INN:BAN]
RN: 284461-73-0
UNII: 9ZOQ3TZI87
InChIKey: MLDQJTXFUGDVEO-UHFFFAOYSA-N

Note

  • A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

Molecular Formula

  • C21-H16-Cl-F3-N4-O3

Molecular Weight

  • 464.8294
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Sorafenib
  • Sorafenib [USAN:INN:BAN]

MeSH Heading

  • Sorafenib

Synonyms

  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
  • 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
  • BAY 43-9006
  • BAY43-9006
  • EC 608-209-4
  • HSDB 8173
  • N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
  • Nexavar
  • Sorafenib
  • UNII-9ZOQ3TZI87

Systematic Names

  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide

Registry Numbers

CAS Registry Number

  • 284461-73-0

FDA UNII

  • 9ZOQ3TZI87

System Generated Number

  • 0284461730

Structure Descriptors

InChI

InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChIKey

MLDQJTXFUGDVEO-UHFFFAOYSA-N

Smiles

CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1