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Substance Name: Sorafenib [USAN:INN:BAN]
RN: 284461-73-0
UNII: 9ZOQ3TZI87
InChIKey: MLDQJTXFUGDVEO-UHFFFAOYSA-N

Note

  • Inhibits tumor cell proliferation and angiogenesis by targeting RAF KINASES and VEGF RECEPTORS; multikinase inhibitor that targets serine/threonine and receptor tyrosine kinases to decrease tumor growth and angiogenesis; FDA approved orphan drug indication for hepatocellular carcinoma in 2006.

Molecular Formula

  • C21-H16-Cl-F3-N4-O3

Molecular Weight

  • 464.8294
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Sorafenib
  • Sorafenib [USAN:INN:BAN]

Synonyms

  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
  • 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
  • BAY 43-9006
  • BAY43-9006
  • EC 608-209-4
  • HSDB 8173
  • N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
  • Nexavar
  • Sorafenib
  • UNII-9ZOQ3TZI87

Systematic Names

  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide

Registry Numbers

CAS Registry Number

  • 284461-73-0

FDA UNII

  • 9ZOQ3TZI87

System Generated Number

  • 0284461730

Structure Descriptors

InChI

1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChIKey

MLDQJTXFUGDVEO-UHFFFAOYSA-N

Smiles

c1(cc(ccc1Cl)NC(Nc1ccc(Oc2ccnc(c2)C(NC)=O)cc1)=O)C(F)(F)F