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Substance Name: Sevoflurane [USAN:USP:INN:BAN:JAN]
RN: 28523-86-6
UNII: 38LVP0K73A
InChIKey: DFEYYRMXOJXZRJ-UHFFFAOYSA-N

Molecular Formula

  • C4-H3-F7-O

Molecular Weight

  • 200.0527
 

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Mutation Data
  • Platelet Aggregation Inhibitors
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Sevoflurane
  • Sevoflurane [USAN:USP:INN:BAN:JAN]

Synonyms

  • 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
  • Bax 3084
  • BRN 2041023
  • Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
  • HSDB 8059
  • MR6S4
  • Petrem
  • Sevofluran
  • Sevoflurane
  • Sevoflurano
  • Sevoflurano [INN-Spanish]
  • Sevofluranum
  • Sevofluranum [INN-Latin]
  • Sojourn
  • Ultane
  • UNII-38LVP0K73A

Systematic Names

  • Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-
  • Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-

Registry Numbers

CAS Registry Number

  • 28523-86-6

FDA UNII

  • 38LVP0K73A

System Generated Number

  • 0028523866

Structure Descriptors

InChI

1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2

InChIKey

DFEYYRMXOJXZRJ-UHFFFAOYSA-N

Smiles

C(OC(C(F)(F)F)C(F)(F)F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC50 inhalation 28300ppm/3H (28300ppm) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 5497, 1987.
mouse LD50 intraperitoneal 10500mg/kg (10500mg/kg)   Drugs in Japan Vol. -, Pg. 591, 1990.
mouse LD50 oral 18200mg/kg (18200mg/kg)   Drugs in Japan Vol. -, Pg. 591, 1990.
rat LC50 inhalation 28800ppm/3H (28800ppm) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 5497, 1987.
rat LD50 intraperitoneal 6300mg/kg (6300mg/kg)   Drugs in Japan Vol. -, Pg. 591, 1990.
rat LD50 oral 10800mg/kg (10800mg/kg)   Drugs in Japan Vol. -, Pg. 591, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
Boiling Point 58.5 deg C   EXP
log P (octanol-water) 1.750 (none)   EST
Vapor Pressure 200 mm Hg 25 EXP
Atmospheric OH Rate Constant 7.30E-14 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.