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Substance Name: Doramapimod [USAN:INN]
RN: 285983-48-4
UNII: HO1A8B3YVV
InChIKey: MVCOAUNKQVWQHZ-UHFFFAOYSA-N

Note

  • P38 MAP kinase inhibitor.

Classification Codes

  • Immunomodulator
  • Treatment of Rheumatoid Arthritis, Crohn's Disease and Psoriasis

Molecular Formula

  • C31-H37-N5-O3

Molecular Weight

  • 527.665
 
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Names and Synonyms

Name of Substance

  • BIRB 796
  • Doramapimod [USAN:INN]

Synonyms

  • 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3(4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl)urea
  • BIRB-796
  • Doramapimod
  • UNII-HO1A8B3YVV
  • Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-(4-(2-(4-morpholinyl)ethoxy)-1-naphthalenyl)-

Systematic Names

  • 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-(4-(2-(4-morpholinyl)ethoxy)-1-naphthalenyl)-

Registry Numbers

CAS Registry Number

  • 285983-48-4

FDA UNII

  • HO1A8B3YVV

System Generated Number

  • 0285983484

Structure Descriptors

InChI

1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChIKey

MVCOAUNKQVWQHZ-UHFFFAOYSA-N

Smiles

N(C(=O)Nc1ccc(c2ccccc12)OCCN1CCOCC1)c1cc(nn1c1ccc(cc1)C)C(C)(C)C