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Substance Name: Rimazolium metilsulfate [INN]
RN: 28610-84-6
UNII: 99YI50276I
InChIKey: SEISMQVOJUJKGE-UHFFFAOYSA-M

Classification Codes

  • Analgesic
  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H19-N2-O3.C-H3-O4-S

Molecular Weight

  • 362.401
 
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Names and Synonyms

Name of Substance

  • Rimazolium metilsulfate
  • Rimazolium metilsulfate [INN]

Synonyms

  • 1,6-Dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol methylsulphate
  • 3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidinium methyl sulfate
  • 3-Ethoxycarbonyl-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidinium methylsulfat
  • Dolcuran
  • EINECS 249-103-4
  • Metilsulfate de rimazolium
  • Metilsulfate de rimazolium [INN-French]
  • Metilsulfato de rimazolio
  • Metilsulfato de rimazolio [INN-Spanish]
  • MZ 0780
  • MZ-144
  • Probon
  • Probonal
  • Rimagina
  • Rimazolii metilsulfas
  • Rimazolii metilsulfas [INN-Latin]
  • Rimazolium methyl sulfate
  • Rimazolium metilsulfate
  • Ro 11-780
  • UNII-99YI50276I

Systematic Names

  • 3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidinium methyl sulfate
  • 4H-Pyrido(1,2-a)pyrimidinium, 6,7,8,9-tetrahydro-3-carboxy-1,6-dimethyl-4-oxo-, ethyl ester, methyl sulfate
  • Rimazolium metilsulfate

Registry Numbers

CAS Registry Number

  • 28610-84-6

FDA UNII

  • 99YI50276I

Related Registry Number

  • 35615-72-6 (Parent)

System Generated Number

  • 0028610846

Molecular Formulas

Molecular Formula

  • C13-H19-N2-O3.C-H3-O4-S

Molecular Formula Fragments

  • C-H3-O4-S
  • C13-H19-N2-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C13H19N2O3.CH4O4S/c1-4-18-13(17)10-8-14(3)11-7-5-6-9(2)15(11)12(10)16;1-5-6(2,3)4/h8-9H,4-7H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1

InChIKey

SEISMQVOJUJKGE-UHFFFAOYSA-M

Smiles

c12CCC[C@@H](n2c(=O)c(C(=O)OCC)c[n+]1C)C.S(=O)(=O)(OC)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 150mg/kg (150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
dog LD50 intravenous 230mg/kg (230mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
dog LD50 oral 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig LD50 intraperitoneal 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig LD50 subcutaneous 420mg/kg (420mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
monkey LD50 oral > 1200mg/kg (1200mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
monkey LD50 subcutaneous > 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rabbit LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 intraperitoneal 720mg/kg (720mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 intravenous 217mg/kg (217mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 717, 1971.
rat LD50 oral 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 subcutaneous 750mg/kg (750mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 727, 1971.