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Substance Name: Hexadimethrine bromide [INN]
RN: 28728-55-4
UNII: 4C905MSK4W
InChIKey: KZKAYEGOIJEWQB-UHFFFAOYSA-N

Note

  • A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.

Molecular Formulas

  • (C13-H30-Br2-N2)mult-
  • (C13-H30-N2)mult-.2Br
  • (C13-H30-N2)n.2Br

Molecular Weight

  • 374.202
 

Classification Codes

  • Coagulants
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Heparin Antagonists
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Names and Synonyms

Results Name

  • Hexadimethrine bromide [INN]

Name of Substance

  • 6,3-Ionene
  • Hexadimethrine bromide
  • Hexadimethrine bromide [INN]

MeSH Heading

  • Hexadimethrine Bromide

Synonyms

  • 6,3-Ionene bromide
  • Hexadimethrine bromide
  • NSC 25133
  • Polybrene
  • UNII-4C905MSK4W

Systematic Names

  • Poly((dimethyliminio)-1,3-propanediyl(dimethyliminio)-1,6-hexanediyl dibromide)
  • Poly((dimethyliminio)hexamethylene(dimethylimino)trimethylene dibromide)

Registry Numbers

CAS Registry Number

  • 28728-55-4

FDA UNII

  • 4C905MSK4W

Other Registry Number

  • 32036-84-3

System Generated Number

  • 0028728554

Molecular Formulas

Molecular Formulas

  • (C13-H30-Br2-N2)mult-
  • (C13-H30-N2)mult-.2Br
  • (C13-H30-N2)n.2Br

Molecular Formula Fragments

  • Br
  • C13-H30-Br2-N2
  • C13-H30-N2
  • COMPONENT

Structure Descriptors

InChI

1S/C10H24N2.C3H6Br2/c1-11(2)9-7-5-6-8-10-12(3)4;4-2-1-3-5/h5-10H2,1-4H3;1-3H2

InChIKey

KZKAYEGOIJEWQB-UHFFFAOYSA-N

Smiles

CN(C)CCCCCCN(C)C.C(CBr)CBr

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 30mg/kg (30mg/kg)   Russian Pharmacology and Toxicology Vol. 37, Pg. 267, 1974.
mouse LD50 intravenous 28mg/kg (28mg/kg)   United States Patent Document. Vol. #4013507,
mouse LD50 oral > 1gm/kg (1000mg/kg)   United States Patent Document. Vol. #4013507,
rat LD50 intravenous 20mg/kg (20mg/kg)   United States Patent Document. Vol. #4013507,