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Substance Name: Cediranib [USAN:INN:BAN]
RN: 288383-20-0
UNII: NQU9IPY4K9
InChIKey: XXJWYDDUDKYVKI-UHFFFAOYSA-N

Notes

  • Indole-ether quinazoline; highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.
  • Indole-ether quinazoline; vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor.

Molecular Formula

  • C25-H27-F-N4-O3

Molecular Weight

  • 450.5113
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Cediranib [USAN:INN:BAN]

Synonyms

  • 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
  • AZD 2171
  • AZD2171
  • Cediranib
  • Recentin
  • UNII-NQU9IPY4K9

Systematic Name

  • Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-

Registry Numbers

CAS Registry Number

  • 288383-20-0

FDA UNII

  • NQU9IPY4K9

Other Registry Numbers

  • 557795-03-6
  • 790713-41-6

System Generated Number

  • 0288383200

Structure Descriptors

InChI

1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3

InChIKey

XXJWYDDUDKYVKI-UHFFFAOYSA-N

Smiles

Cc1cc2c([nH]1)ccc(c2F)Oc3c4cc(c(cc4ncn3)OCCCN5CCCC5)OC